HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates
One of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain human papillomaviruses (HPV) genotypes as the cause of cervical cancer. Since then, a range of diagnostic and therapeutic methods has been developed based on this discovery....
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-02-01
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| Series: | Current Oncology |
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| Online Access: | https://www.mdpi.com/1718-7729/32/3/122 |
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| author | Emilia Włoszek Kamila Krupa Eliza Skrok Michał Piotr Budzik Andrzej Deptała Anna Badowska-Kozakiewicz |
| author_facet | Emilia Włoszek Kamila Krupa Eliza Skrok Michał Piotr Budzik Andrzej Deptała Anna Badowska-Kozakiewicz |
| author_sort | Emilia Włoszek |
| collection | DOAJ |
| description | One of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain human papillomaviruses (HPV) genotypes as the cause of cervical cancer. Since then, a range of diagnostic and therapeutic methods has been developed based on this discovery. This article aims to describe the latest updates in the biology, prevention, and treatment of HPV-related cervical cancer. The current state of knowledge regarding vaccinations, diagnostic tests, and cervical cancer therapies is presented. The latest WHO guidelines on vaccinations are presented, as well as announcements of upcoming changes. The final part of the article summarizes promising new diagnostic and treatment methods, as well as perspectives and the latest research findings on self-administered diagnostic tests, the use of therapeutic vaccines, and circulating cell-free DNA in diagnosis. Despite the significant progress made in recent years, the strategy based on vaccination and testing remains the cornerstone in the fight against HPV-related cervical cancer. |
| format | Article |
| id | doaj-art-309700d24b2a4dedbc47ff500e1d6780 |
| institution | DOAJ |
| issn | 1198-0052 1718-7729 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Current Oncology |
| spelling | doaj-art-309700d24b2a4dedbc47ff500e1d67802025-08-20T02:42:42ZengMDPI AGCurrent Oncology1198-00521718-77292025-02-0132312210.3390/curroncol32030122HPV and Cervical Cancer—Biology, Prevention, and Treatment UpdatesEmilia Włoszek0Kamila Krupa1Eliza Skrok2Michał Piotr Budzik3Andrzej Deptała4Anna Badowska-Kozakiewicz5Students’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandStudents’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandStudents’ Scientific Organization of Cancer Cell Biology, Department of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Oncology Propaedeutics, Medical University of Warsaw, 02-091 Warsaw, PolandOne of the most significant breakthroughs in cancer research has been the identification of persistent infection with certain human papillomaviruses (HPV) genotypes as the cause of cervical cancer. Since then, a range of diagnostic and therapeutic methods has been developed based on this discovery. This article aims to describe the latest updates in the biology, prevention, and treatment of HPV-related cervical cancer. The current state of knowledge regarding vaccinations, diagnostic tests, and cervical cancer therapies is presented. The latest WHO guidelines on vaccinations are presented, as well as announcements of upcoming changes. The final part of the article summarizes promising new diagnostic and treatment methods, as well as perspectives and the latest research findings on self-administered diagnostic tests, the use of therapeutic vaccines, and circulating cell-free DNA in diagnosis. Despite the significant progress made in recent years, the strategy based on vaccination and testing remains the cornerstone in the fight against HPV-related cervical cancer.https://www.mdpi.com/1718-7729/32/3/122human papillomavirusHPVcervical cancervaccinationscreeningsystemic therapy |
| spellingShingle | Emilia Włoszek Kamila Krupa Eliza Skrok Michał Piotr Budzik Andrzej Deptała Anna Badowska-Kozakiewicz HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates Current Oncology human papillomavirus HPV cervical cancer vaccination screening systemic therapy |
| title | HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates |
| title_full | HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates |
| title_fullStr | HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates |
| title_full_unstemmed | HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates |
| title_short | HPV and Cervical Cancer—Biology, Prevention, and Treatment Updates |
| title_sort | hpv and cervical cancer biology prevention and treatment updates |
| topic | human papillomavirus HPV cervical cancer vaccination screening systemic therapy |
| url | https://www.mdpi.com/1718-7729/32/3/122 |
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