Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration
Optical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal struct...
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MDPI AG
2025-03-01
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| Series: | Photonics |
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| Online Access: | https://www.mdpi.com/2304-6732/12/3/237 |
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| author | Serena Fragiotta Mariachiara Di Pippo Daniele Fumi Chiara Ciancimino Solmaz Abdolrahimzadeh |
| author_facet | Serena Fragiotta Mariachiara Di Pippo Daniele Fumi Chiara Ciancimino Solmaz Abdolrahimzadeh |
| author_sort | Serena Fragiotta |
| collection | DOAJ |
| description | Optical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal structures comparable to an in vivo histopathology. Recent histopathological correlations with OCT have enabled the precise characterization of AMD extracellular lesions, improving the interpretation of several OCT signatures. By correlating OCT findings with clinicopathological features, a deeper understanding of the underlying pathophysiology of AMD is achieved, facilitating early detection, risk stratification, and therapeutic decision making. Furthermore, OCT-derived biomarkers offer valuable insights into disease severity, response to treatment, and prognostic outcomes, thereby enhancing patient care and optimizing visual outcomes. |
| format | Article |
| id | doaj-art-3095fcb7b2de47648045ebd58bb43491 |
| institution | Kabale University |
| issn | 2304-6732 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
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| series | Photonics |
| spelling | doaj-art-3095fcb7b2de47648045ebd58bb434912025-08-20T03:43:20ZengMDPI AGPhotonics2304-67322025-03-0112323710.3390/photonics12030237Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular DegenerationSerena Fragiotta0Mariachiara Di Pippo1Daniele Fumi2Chiara Ciancimino3Solmaz Abdolrahimzadeh4Ophthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, ItalyOphthalmology Unit, Neurosciences, Mental Health, and Sense Organs (NESMOS) Department, Faculty of Medicine and Psychology, University of Rome Sapienza, 00189 Rome, ItalyOptical coherence tomography (OCT) has emerged as a pivotal imaging modality in elucidating the pathogenic, clinical, and prognostic implications of age-related macular degeneration (AMD). This review examines the utility of OCT in providing high-resolution, cross-sectional imaging of retinal structures comparable to an in vivo histopathology. Recent histopathological correlations with OCT have enabled the precise characterization of AMD extracellular lesions, improving the interpretation of several OCT signatures. By correlating OCT findings with clinicopathological features, a deeper understanding of the underlying pathophysiology of AMD is achieved, facilitating early detection, risk stratification, and therapeutic decision making. Furthermore, OCT-derived biomarkers offer valuable insights into disease severity, response to treatment, and prognostic outcomes, thereby enhancing patient care and optimizing visual outcomes.https://www.mdpi.com/2304-6732/12/3/237optical coherence tomographyage-related macular degenerationretinacrystalline depositsouter retinal tubulationshyperreflective foci |
| spellingShingle | Serena Fragiotta Mariachiara Di Pippo Daniele Fumi Chiara Ciancimino Solmaz Abdolrahimzadeh Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration Photonics optical coherence tomography age-related macular degeneration retina crystalline deposits outer retinal tubulations hyperreflective foci |
| title | Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration |
| title_full | Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration |
| title_fullStr | Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration |
| title_full_unstemmed | Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration |
| title_short | Optical Coherence Tomography and Clinicopathological Correlation for Understanding the Pathogenic, Clinical, and Prognostic Implications in Age-Related Macular Degeneration |
| title_sort | optical coherence tomography and clinicopathological correlation for understanding the pathogenic clinical and prognostic implications in age related macular degeneration |
| topic | optical coherence tomography age-related macular degeneration retina crystalline deposits outer retinal tubulations hyperreflective foci |
| url | https://www.mdpi.com/2304-6732/12/3/237 |
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