Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature

Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we pres...

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Main Authors: Sepideh Mokhtari, Zhaleh Mohsenifar, Maedeh Ghorbanpour
Format: Article
Language:English
Published: Wiley 2013-01-01
Series:Case Reports in Pathology
Online Access:http://dx.doi.org/10.1155/2013/853095
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author Sepideh Mokhtari
Zhaleh Mohsenifar
Maedeh Ghorbanpour
author_facet Sepideh Mokhtari
Zhaleh Mohsenifar
Maedeh Ghorbanpour
author_sort Sepideh Mokhtari
collection DOAJ
description Calcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.
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spelling doaj-art-3092feff42bd4c46bec4ca8cbc47e2f82025-02-03T06:12:12ZengWileyCase Reports in Pathology2090-67812090-679X2013-01-01201310.1155/2013/853095853095Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the LiteratureSepideh Mokhtari0Zhaleh Mohsenifar1Maedeh Ghorbanpour2Department of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranDepartment of Pathology, Taleghani Hospital, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranDepartment of Oral and Maxillofacial Pathology, School of Dentistry, Shahid Beheshti University of Medical Sciences, Tehran 1983969411, IranCalcifying cystic odontogenic tumor (CCOT) demonstrates considerable diversity in histopathology and clinical behavior. Ghost cell odontogenic carcinoma (GCOC) is the rare malignant counterpart of CCOT and it frequently arises from malignant transformation of a recurrent CCOT. In this paper, we present a case of CCOT and discuss its distinct histopathologic features in recurrence. Then, we will have a review on clinical, histopathological, and immunohistochemical aspects of GCOC in the literature. Predictive factors of malignant transformation in a benign CCOT will also be discussed.http://dx.doi.org/10.1155/2013/853095
spellingShingle Sepideh Mokhtari
Zhaleh Mohsenifar
Maedeh Ghorbanpour
Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
Case Reports in Pathology
title Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
title_full Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
title_fullStr Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
title_full_unstemmed Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
title_short Predictive Factors of Potential Malignant Transformation in Recurrent Calcifying Cystic Odontogenic Tumor: Review of the Literature
title_sort predictive factors of potential malignant transformation in recurrent calcifying cystic odontogenic tumor review of the literature
url http://dx.doi.org/10.1155/2013/853095
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