High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials
<b>Background/Objectives</b>: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents...
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MDPI AG
2025-03-01
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| author | Konstantina Liva Athanasios A. Panagiotopoulos Alexandra Foscolou Charalampia Amerikanou Alkistis Vitali Stavros Zioulis Konstantina Argyri Georgios I. Panoutsopoulos Andriana C. Kaliora Aristea Gioxari |
| author_facet | Konstantina Liva Athanasios A. Panagiotopoulos Alexandra Foscolou Charalampia Amerikanou Alkistis Vitali Stavros Zioulis Konstantina Argyri Georgios I. Panoutsopoulos Andriana C. Kaliora Aristea Gioxari |
| author_sort | Konstantina Liva |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical studies examining the anti-obesity effects of high phenolic extra virgin olive oil (HP-EVOO) and its possible underlying molecular mechanisms. <b>Methods:</b> Studies published between 2014 and 2024 were searched via MEDLINE, Scopus, Cochrane, the Web of Science, Semantic Scholar, Google Scholar, Science.gov, and Clinicaltrials.gov databases. A combination of keywords and Boolean logic was used to search throughout the last decade in all databases, including “hyperglycemia” or “hypertension” or “metabolic syndrome” or “dyslipidemia” or “hyperlipidemia” or “hypoglycemia” or “obesity” or “macrovascular diabetic complications” or “microvascular diabetic complications” or “cardiovascular disease” or “overweight” or “insulin sensitivity” or “insulin resistance” and “extra virgin olive oil” or “high phenolic olive oil” and “human” or “animal model”. <b>Results</b>: The 10-year literature survey identified 21 studies in both animal models and humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress and endothelial function, potentially protecting against metabolic syndrome, hypertension and type 2 diabetes, even compared to EVOO. Moreover, HP-EVOO’s antiplatelet effect and improvement in HDL functionality reduce cardiovascular risk. <b>Conclusions</b>: The evidence presented in this study demonstrates that HP-EVOO represents an effective preventive and therapeutic dietary approach to cardiometabolic diseases. |
| format | Article |
| id | doaj-art-308d00a45fd2490a8d18ceb9ff2161af |
| institution | Kabale University |
| issn | 2039-7283 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Clinics and Practice |
| spelling | doaj-art-308d00a45fd2490a8d18ceb9ff2161af2025-08-20T03:43:11ZengMDPI AGClinics and Practice2039-72832025-03-011535410.3390/clinpract15030054High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical TrialsKonstantina Liva0Athanasios A. Panagiotopoulos1Alexandra Foscolou2Charalampia Amerikanou3Alkistis Vitali4Stavros Zioulis5Konstantina Argyri6Georgios I. Panoutsopoulos7Andriana C. Kaliora8Aristea Gioxari9Department of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave., 17676 Athens, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, GreeceDepartment of Dietetics and Nutritional Science, School of Health Science and Education, Harokopio University, 70 El. Venizelou Ave., 17676 Athens, GreeceDepartment of Nutritional Science and Dietetics, School of Health Sciences, University of the Peloponnese, Antikalamos, 24100 Kalamata, Greece<b>Background/Objectives</b>: During the last decade, there has been an increased interest in phenolic compound-rich natural products as natural therapies for regulating the molecular pathways behind central obesity and associated metabolic disorders. The present scoping review presents the outcomes of clinical and preclinical studies examining the anti-obesity effects of high phenolic extra virgin olive oil (HP-EVOO) and its possible underlying molecular mechanisms. <b>Methods:</b> Studies published between 2014 and 2024 were searched via MEDLINE, Scopus, Cochrane, the Web of Science, Semantic Scholar, Google Scholar, Science.gov, and Clinicaltrials.gov databases. A combination of keywords and Boolean logic was used to search throughout the last decade in all databases, including “hyperglycemia” or “hypertension” or “metabolic syndrome” or “dyslipidemia” or “hyperlipidemia” or “hypoglycemia” or “obesity” or “macrovascular diabetic complications” or “microvascular diabetic complications” or “cardiovascular disease” or “overweight” or “insulin sensitivity” or “insulin resistance” and “extra virgin olive oil” or “high phenolic olive oil” and “human” or “animal model”. <b>Results</b>: The 10-year literature survey identified 21 studies in both animal models and humans, indicating that HP-EVOO improves inflammation, glycemic control, oxidative stress and endothelial function, potentially protecting against metabolic syndrome, hypertension and type 2 diabetes, even compared to EVOO. Moreover, HP-EVOO’s antiplatelet effect and improvement in HDL functionality reduce cardiovascular risk. <b>Conclusions</b>: The evidence presented in this study demonstrates that HP-EVOO represents an effective preventive and therapeutic dietary approach to cardiometabolic diseases.https://www.mdpi.com/2039-7283/15/3/54extra virgin olive oilpolyphenolsobesitymetabolic syndromehydroxytyrosoltyrosol |
| spellingShingle | Konstantina Liva Athanasios A. Panagiotopoulos Alexandra Foscolou Charalampia Amerikanou Alkistis Vitali Stavros Zioulis Konstantina Argyri Georgios I. Panoutsopoulos Andriana C. Kaliora Aristea Gioxari High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials Clinics and Practice extra virgin olive oil polyphenols obesity metabolic syndrome hydroxytyrosol tyrosol |
| title | High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials |
| title_full | High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials |
| title_fullStr | High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials |
| title_full_unstemmed | High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials |
| title_short | High Polyphenol Extra Virgin Olive Oil and Metabolically Unhealthy Obesity: A Scoping Review of Preclinical Data and Clinical Trials |
| title_sort | high polyphenol extra virgin olive oil and metabolically unhealthy obesity a scoping review of preclinical data and clinical trials |
| topic | extra virgin olive oil polyphenols obesity metabolic syndrome hydroxytyrosol tyrosol |
| url | https://www.mdpi.com/2039-7283/15/3/54 |
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