TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT
Objective: to study the time course of rituximab therapy-induced changes in the synovial fluid levels of osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), interleukins (IL) 1β and 6, and tumor necrosis factor-α (TNF-α) in patients with rheumatoid arthritis (RA). Res...
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| Format: | Article |
| Language: | Russian |
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IMA PRESS LLC
2011-08-01
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| Series: | Научно-практическая ревматология |
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| Online Access: | https://rsp.mediar-press.net/rsp/article/view/345 |
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| author | A V Bezgin L A Knyazeva |
| author_facet | A V Bezgin L A Knyazeva |
| author_sort | A V Bezgin |
| collection | DOAJ |
| description | Objective: to study the time course of rituximab therapy-induced changes in the synovial fluid levels of osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), interleukins (IL) 1β and 6, and tumor necrosis factor-α (TNF-α) in patients with rheumatoid arthritis (RA). Results and discussion. The synovial fluid levels of IL-1ß, IL-6, TNF-α, OPG, and RANKL were studied in 54 RA patients who were seropositive for rheumatoid factor and cyclic citrullinated peptide. Differences were found in the levels of the study cytokines in patients with a varying duration of the disease. Conclusion. Rituximab was observed to be highly effective in correcting cytokine parameters in early RA. |
| format | Article |
| id | doaj-art-308c9e1662064202bd835d2bfc76b858 |
| institution | DOAJ |
| issn | 1995-4484 1995-4492 |
| language | Russian |
| publishDate | 2011-08-01 |
| publisher | IMA PRESS LLC |
| record_format | Article |
| series | Научно-практическая ревматология |
| spelling | doaj-art-308c9e1662064202bd835d2bfc76b8582025-08-20T03:21:51ZrusIMA PRESS LLCНаучно-практическая ревматология1995-44841995-44922011-08-01494444610.14412/1995-4484-2011-61285TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENTA V BezginL A KnyazevaObjective: to study the time course of rituximab therapy-induced changes in the synovial fluid levels of osteoprotegerin (OPG), receptor activator of nuclear factor kappa-B ligand (RANKL), interleukins (IL) 1β and 6, and tumor necrosis factor-α (TNF-α) in patients with rheumatoid arthritis (RA). Results and discussion. The synovial fluid levels of IL-1ß, IL-6, TNF-α, OPG, and RANKL were studied in 54 RA patients who were seropositive for rheumatoid factor and cyclic citrullinated peptide. Differences were found in the levels of the study cytokines in patients with a varying duration of the disease. Conclusion. Rituximab was observed to be highly effective in correcting cytokine parameters in early RA.https://rsp.mediar-press.net/rsp/article/view/345proinflammatory cytokinesrituximabrheumatoid arthritis |
| spellingShingle | A V Bezgin L A Knyazeva TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT Научно-практическая ревматология proinflammatory cytokines rituximab rheumatoid arthritis |
| title | TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT |
| title_full | TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT |
| title_fullStr | TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT |
| title_full_unstemmed | TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT |
| title_short | TIME COURSE OF CHANGES IN THE SYNOVIAL FLUID LEVELS OF PROINFLAMMATORY CYTOKINES IN RHEUMATOID ATHRITIS PATIENTS DURING RITUXIMAB TREATMENT |
| title_sort | time course of changes in the synovial fluid levels of proinflammatory cytokines in rheumatoid athritis patients during rituximab treatment |
| topic | proinflammatory cytokines rituximab rheumatoid arthritis |
| url | https://rsp.mediar-press.net/rsp/article/view/345 |
| work_keys_str_mv | AT avbezgin timecourseofchangesinthesynovialfluidlevelsofproinflammatorycytokinesinrheumatoidathritispatientsduringrituximabtreatment AT laknyazeva timecourseofchangesinthesynovialfluidlevelsofproinflammatorycytokinesinrheumatoidathritispatientsduringrituximabtreatment |