Acute Respiratory Distress Syndrome: 30 Years Later?
Acute respiratory distress syndrome (ARDS) was first described about 30 years ago. Modern definitions and statements have recently been proposed to describe ARDS accurately, but none is perfect. Diffuse alveolar damage is the basic pathological pattern most commonly observed in ARDS, and the term in...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1999-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/1999/812476 |
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| _version_ | 1849306098418319360 |
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| author | Olivier Lesur Yves Berthiaume Gilbert Blaise Pierre Damas Éric Deland Jean-Gilles Guimond René P Michel |
| author_facet | Olivier Lesur Yves Berthiaume Gilbert Blaise Pierre Damas Éric Deland Jean-Gilles Guimond René P Michel |
| author_sort | Olivier Lesur |
| collection | DOAJ |
| description | Acute respiratory distress syndrome (ARDS) was first described about 30 years ago. Modern definitions and statements have recently been proposed to describe ARDS accurately, but none is perfect. Diffuse alveolar damage is the basic pathological pattern most commonly observed in ARDS, and the term includes permeability edema. The alveolar epithelium of the alveolar-capillary barrier is clearly a key component requiring repair, given its multipotent functional activity. Lung inflammation and neutrophil accumulation are essential markers of disease in ARDS, and a wide variety of pro- and anti-inflammatory cytokines have been described in the alveolar fluid and blood of patients. These molecules still have to prove their value as diagnostic or prognostic biomarkers of ARDS. |
| format | Article |
| id | doaj-art-308aee062e8244048c7def04de659b08 |
| institution | Kabale University |
| issn | 1198-2241 |
| language | English |
| publishDate | 1999-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-308aee062e8244048c7def04de659b082025-08-20T03:55:12ZengWileyCanadian Respiratory Journal1198-22411999-01-0161718610.1155/1999/812476Acute Respiratory Distress Syndrome: 30 Years Later?Olivier Lesur0Yves Berthiaume1Gilbert Blaise2Pierre Damas3Éric Deland4Jean-Gilles Guimond5René P Michel6Soins Intensifs Médico-Chirurgicaux, Département de Médecine, CUSE Sherbrooke, Sherbrooke, CanadaCentre de Recherche, CHUM, Département de Médecine, Montréal, CanadaDépartement d’Anesthésie, Pavillon Notre-Dame CHUM, Montréal, CanadaSoins Intensifs Généraux, CHU de Liège, BelgiumSoins Intensifs Médico-Chirurgicaux, Département de Médecine, CUSE Sherbrooke, Sherbrooke, CanadaSoins Intensifs Médicaux, Pavillon Notre-Dame CHUM, Montréal, CanadaDepartment of Pathology, Lyman Duff Medical Sciences Building, McGill University, Montréal, Quebec, CanadaAcute respiratory distress syndrome (ARDS) was first described about 30 years ago. Modern definitions and statements have recently been proposed to describe ARDS accurately, but none is perfect. Diffuse alveolar damage is the basic pathological pattern most commonly observed in ARDS, and the term includes permeability edema. The alveolar epithelium of the alveolar-capillary barrier is clearly a key component requiring repair, given its multipotent functional activity. Lung inflammation and neutrophil accumulation are essential markers of disease in ARDS, and a wide variety of pro- and anti-inflammatory cytokines have been described in the alveolar fluid and blood of patients. These molecules still have to prove their value as diagnostic or prognostic biomarkers of ARDS.http://dx.doi.org/10.1155/1999/812476 |
| spellingShingle | Olivier Lesur Yves Berthiaume Gilbert Blaise Pierre Damas Éric Deland Jean-Gilles Guimond René P Michel Acute Respiratory Distress Syndrome: 30 Years Later? Canadian Respiratory Journal |
| title | Acute Respiratory Distress Syndrome: 30 Years Later? |
| title_full | Acute Respiratory Distress Syndrome: 30 Years Later? |
| title_fullStr | Acute Respiratory Distress Syndrome: 30 Years Later? |
| title_full_unstemmed | Acute Respiratory Distress Syndrome: 30 Years Later? |
| title_short | Acute Respiratory Distress Syndrome: 30 Years Later? |
| title_sort | acute respiratory distress syndrome 30 years later |
| url | http://dx.doi.org/10.1155/1999/812476 |
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