F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression

F-box protein FBXO32 ubiquitinates and stabilizes D-type cyclins to drive cancer progression

Abstract D-type cyclins (hereafter, cyclin D) are central regulators orchestrating G1/S cell cycle transition. Accordingly, aberrant expression of cyclin D is strongly correlated with proliferation-related diseases such as cancer. However, the mechanisms regulating cyclin D turnover are incompletely...

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Bibliographic Details
Main Authors: Feng Li, Hongqiang Yu, Yujun Zhang, Yuanhang Ma, Xinlei Chen, Jie Zhang, Liangbo Sun, Rui Guo, Ying Wu, Ping Zheng, Xiaojun Wang, Ping Bie, Fengtian He, Leida Zhang, Chuanming Xie, Haojun Xiong
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-59407-9
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