Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020
Abstract Background Traumatic Brain Injury (TBI) is a critical public health issue in the United States, contributing significantly to morbidity, mortality, and healthcare costs. Accounting for a substantial proportion of injury-related deaths and disabilities, TBI impacts a wide demographic, with p...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-02-01
|
| Series: | BMC Public Health |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12889-025-21657-z |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823861538761474048 |
|---|---|
| author | Muhammad Hamza Dawood Yusra Fazli Sejal Lund Shurjeel Uddin Qazi Rija Tahir Areehah Zafar Masood Aiman Azam Qureshi Saleha Safdar Heraa Zaheer Muhammad TayyabMuzaffar Chaychi |
| author_facet | Muhammad Hamza Dawood Yusra Fazli Sejal Lund Shurjeel Uddin Qazi Rija Tahir Areehah Zafar Masood Aiman Azam Qureshi Saleha Safdar Heraa Zaheer Muhammad TayyabMuzaffar Chaychi |
| author_sort | Muhammad Hamza Dawood |
| collection | DOAJ |
| description | Abstract Background Traumatic Brain Injury (TBI) is a critical public health issue in the United States, contributing significantly to morbidity, mortality, and healthcare costs. Accounting for a substantial proportion of injury-related deaths and disabilities, TBI impacts a wide demographic, with particularly high incidence rates among young and elderly populations. Despite earlier declines, recent years have seen an uptick in TBI-related fatalities. This study aimed to evaluate the patterns and geographical disparities in mortality related to TBI among the adult population in the United States. Methods We examined the death certificates sourced from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database to identify adults in whom TBI was documented as an underlying or contributing cause of death between 1999 and 2020. Age-adjusted mortality rates (AAMRs) per 100,000 individuals and annual percent change (APC) were computed and stratified based on year, gender, race/ethnicity, and geographic region. Results Between 1999 and 2020, 1,026,185 TBI-related deaths occurred among adults aged ≥ 25 years. The AAMR remained stable from 22.2 in 1999 to 22.3 in 2007, followed by an insignificant decline to 21.5 in 2010, and a steeper significant subsequent increase to 24.6 in 2020. Men had consistently higher AAMR than women from 1999 (men: 35.6; women: 11.1) to 2020 (men: 38.8; women: 11.9). The 85 + years age group had the highest AAMR 118.5 trailed by 75–84-year age group at 53.2. American Indian or Alaska Native adults had the highest AAMR (31.9) followed by White (24.4). South had the highest AAMR (25.3), followed by West (22.7). Non-metropolitan areas consistently had higher mortality rates compared to metropolitan areas. Conclusions Following a brief period of stability in TBI-related mortality from 1999 to 2010, there has been a subsequent increase of 1.3% per year in mortality till 2020. Notable geographic and demographic disparities persist, underscoring the need for further research and precise health policy interventions to better understand and address these differences. |
| format | Article |
| id | doaj-art-307fce4d5ed643de9988550c58b94728 |
| institution | Kabale University |
| issn | 1471-2458 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Public Health |
| spelling | doaj-art-307fce4d5ed643de9988550c58b947282025-02-09T12:58:12ZengBMCBMC Public Health1471-24582025-02-0125111210.1186/s12889-025-21657-zMortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020Muhammad Hamza Dawood0Yusra Fazli1Sejal Lund2Shurjeel Uddin Qazi3Rija Tahir4Areehah Zafar Masood5Aiman Azam Qureshi6Saleha Safdar7Heraa Zaheer8Muhammad TayyabMuzaffar Chaychi9Department of Surgery, United Medical and Dental CollegeZiauddin Medical CollegeShaheed Mohtarma Benazir Bhutto Medical CollegeDepartment of Surgery, Dow University of Health SciencesZiauddin Medical CollegeZiauddin Medical CollegeJinnah Sindh Medical UniversityZiauddin Medical CollegeZiauddin Medical CollegeDepartment of Neurology, University of South Florida Morsani College of MedicineAbstract Background Traumatic Brain Injury (TBI) is a critical public health issue in the United States, contributing significantly to morbidity, mortality, and healthcare costs. Accounting for a substantial proportion of injury-related deaths and disabilities, TBI impacts a wide demographic, with particularly high incidence rates among young and elderly populations. Despite earlier declines, recent years have seen an uptick in TBI-related fatalities. This study aimed to evaluate the patterns and geographical disparities in mortality related to TBI among the adult population in the United States. Methods We examined the death certificates sourced from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research (CDC WONDER) database to identify adults in whom TBI was documented as an underlying or contributing cause of death between 1999 and 2020. Age-adjusted mortality rates (AAMRs) per 100,000 individuals and annual percent change (APC) were computed and stratified based on year, gender, race/ethnicity, and geographic region. Results Between 1999 and 2020, 1,026,185 TBI-related deaths occurred among adults aged ≥ 25 years. The AAMR remained stable from 22.2 in 1999 to 22.3 in 2007, followed by an insignificant decline to 21.5 in 2010, and a steeper significant subsequent increase to 24.6 in 2020. Men had consistently higher AAMR than women from 1999 (men: 35.6; women: 11.1) to 2020 (men: 38.8; women: 11.9). The 85 + years age group had the highest AAMR 118.5 trailed by 75–84-year age group at 53.2. American Indian or Alaska Native adults had the highest AAMR (31.9) followed by White (24.4). South had the highest AAMR (25.3), followed by West (22.7). Non-metropolitan areas consistently had higher mortality rates compared to metropolitan areas. Conclusions Following a brief period of stability in TBI-related mortality from 1999 to 2010, there has been a subsequent increase of 1.3% per year in mortality till 2020. Notable geographic and demographic disparities persist, underscoring the need for further research and precise health policy interventions to better understand and address these differences.https://doi.org/10.1186/s12889-025-21657-zTraumatic brain injuryMortality trendsAdultUnited StatesCDC WONDERJoinpoint analysis |
| spellingShingle | Muhammad Hamza Dawood Yusra Fazli Sejal Lund Shurjeel Uddin Qazi Rija Tahir Areehah Zafar Masood Aiman Azam Qureshi Saleha Safdar Heraa Zaheer Muhammad TayyabMuzaffar Chaychi Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 BMC Public Health Traumatic brain injury Mortality trends Adult United States CDC WONDER Joinpoint analysis |
| title | Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 |
| title_full | Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 |
| title_fullStr | Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 |
| title_full_unstemmed | Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 |
| title_short | Mortality trends of traumatic brain injuries in the adult population of the United States: a CDC WONDER analysis from 1999 to 2020 |
| title_sort | mortality trends of traumatic brain injuries in the adult population of the united states a cdc wonder analysis from 1999 to 2020 |
| topic | Traumatic brain injury Mortality trends Adult United States CDC WONDER Joinpoint analysis |
| url | https://doi.org/10.1186/s12889-025-21657-z |
| work_keys_str_mv | AT muhammadhamzadawood mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT yusrafazli mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT sejallund mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT shurjeeluddinqazi mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT rijatahir mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT areehahzafarmasood mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT aimanazamqureshi mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT salehasafdar mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT heraazaheer mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 AT muhammadtayyabmuzaffarchaychi mortalitytrendsoftraumaticbraininjuriesintheadultpopulationoftheunitedstatesacdcwonderanalysisfrom1999to2020 |