Lipid metabolism in myeloid cell function and chronic inflammatory diseases
Immune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response. Recent studies have elucidated that during immune cell metabolic reprogramming, lipid metabolism, including lipid uptake, de novo lipid synthe...
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| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495853/full |
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| author | Ayaka Ito Ayaka Ito Ayaka Ito Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami |
| author_facet | Ayaka Ito Ayaka Ito Ayaka Ito Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami |
| author_sort | Ayaka Ito |
| collection | DOAJ |
| description | Immune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response. Recent studies have elucidated that during immune cell metabolic reprogramming, lipid metabolism, including lipid uptake, de novo lipid synthesis and fatty acid oxidation, undergoes significant alteration, resulting in dynamic changes in the quantity and quality of intracellular lipids. Given that lipids serve as an energy source and structural components of cellular membranes, they have important implications for physiological function. Myeloid cells, which are essential in bridging innate and adaptive immunity, are sensitive to these changes. Dysregulation of lipid metabolism in myeloid cells can result in immune dysfunction, chronic inflammation and impaired resolution of inflammation. Understanding the mechanism by which lipids regulate immune cell function might provide novel therapeutic insights into chronic inflammatory diseases, including metabolic diseases, autoimmune diseases and cancer. (143 words) |
| format | Article |
| id | doaj-art-307a878304ac4feb9641a779892ec77b |
| institution | Kabale University |
| issn | 1664-3224 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj-art-307a878304ac4feb9641a779892ec77b2025-01-22T05:19:33ZengFrontiers Media S.A.Frontiers in Immunology1664-32242025-01-011510.3389/fimmu.2024.14958531495853Lipid metabolism in myeloid cell function and chronic inflammatory diseasesAyaka Ito0Ayaka Ito1Ayaka Ito2Takayoshi Suganami3Takayoshi Suganami4Takayoshi Suganami5Takayoshi Suganami6Department of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanDepartment of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, JapanInstitute for Advanced Research, Nagoya University, Nagoya, JapanDepartment of Molecular Medicine and Metabolism, Research Institute of Environmental Medicine, Nagoya University, Nagoya, JapanDepartment of Immunometabolism, Nagoya University Graduate School of Medicine, Nagoya, JapanInstitute of Nano-Life-Systems, Institutes of Innovation for Future Society, Nagoya University, Nagoya, JapanCenter for One Medicine Innovative Translational Research (COMIT), Nagoya University, Nagoya, JapanImmune cells adapt their metabolism in response to their differentiation and activation status to meet the energy demands for an appropriate immune response. Recent studies have elucidated that during immune cell metabolic reprogramming, lipid metabolism, including lipid uptake, de novo lipid synthesis and fatty acid oxidation, undergoes significant alteration, resulting in dynamic changes in the quantity and quality of intracellular lipids. Given that lipids serve as an energy source and structural components of cellular membranes, they have important implications for physiological function. Myeloid cells, which are essential in bridging innate and adaptive immunity, are sensitive to these changes. Dysregulation of lipid metabolism in myeloid cells can result in immune dysfunction, chronic inflammation and impaired resolution of inflammation. Understanding the mechanism by which lipids regulate immune cell function might provide novel therapeutic insights into chronic inflammatory diseases, including metabolic diseases, autoimmune diseases and cancer. (143 words)https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495853/fulllipid metabolismimmunometabolismautoimmunitycancermetabolic disease |
| spellingShingle | Ayaka Ito Ayaka Ito Ayaka Ito Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami Takayoshi Suganami Lipid metabolism in myeloid cell function and chronic inflammatory diseases Frontiers in Immunology lipid metabolism immunometabolism autoimmunity cancer metabolic disease |
| title | Lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| title_full | Lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| title_fullStr | Lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| title_full_unstemmed | Lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| title_short | Lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| title_sort | lipid metabolism in myeloid cell function and chronic inflammatory diseases |
| topic | lipid metabolism immunometabolism autoimmunity cancer metabolic disease |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2024.1495853/full |
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