Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways

Sporadic ALS hiPSC-derived motor neurons show axonal defects linked to altered axon guidance pathways

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder characterized by the selective and progressive loss of motor neurons, leading to gradual paralysis and death within 2 to 5 years after diagnosis. The exact underlying pathogenic mechanism(s) remain elusive. This is parti...

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Bibliographic Details
Main Authors: Lisha Ye, Katarina Stoklund Dittlau, Adria Sicart, Rekin'’s Janky, Philip Van Damme, Ludo Van Den Bosch
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis (ALS)
Sporadic ALS
Human induced pluripotent stem cells (hiPSCs)
Axonal transport
Axonal outgrowth
Neuromuscular junctions
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996125000312
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