Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs

Distinct release properties of glutamate/GABA co-transmission serve as a frequency-dependent filtering of supramammillary inputs

Glutamate and GABA co-transmitting neurons exist in several brain regions; however, the mechanism by which these two neurotransmitters are co-released from the same synaptic terminals remains unclear. Here, we show that the supramammillary nucleus (SuM) to dentate granule cell synapses, which co-rel...

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Bibliographic Details
Main Authors: Himawari Hirai, Kohtarou Konno, Miwako Yamasaki, Masahiko Watanabe, Takeshi Sakaba, Yuki Hashimotodani
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
co-release
supramammillary nucleus
hippocampus
short-term plasticity
dentate gyrus
synaptic transmission
Online Access:https://elifesciences.org/articles/99711
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