Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer
Abstract This study evaluated the prognostic value of the pan-immune-inflammation value (PIV) combined with the albumin-to-globulin ratio (AGR) for postoperative survival in colorectal cancer (CRC) patients and developed a nomogram for survival prediction. A total of 650 CRC patients who underwent r...
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Nature Portfolio
2025-04-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-96592-5 |
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| author | Kejin Li Yi Chen Ziyi Zhang Kuan Wang Subinur Sulayman Xiangyue Zeng Saibihutula Ababaike Junmin Guan Zeliang Zhao |
| author_facet | Kejin Li Yi Chen Ziyi Zhang Kuan Wang Subinur Sulayman Xiangyue Zeng Saibihutula Ababaike Junmin Guan Zeliang Zhao |
| author_sort | Kejin Li |
| collection | DOAJ |
| description | Abstract This study evaluated the prognostic value of the pan-immune-inflammation value (PIV) combined with the albumin-to-globulin ratio (AGR) for postoperative survival in colorectal cancer (CRC) patients and developed a nomogram for survival prediction. A total of 650 CRC patients who underwent radical surgery were included, with data from one institution used as the training set. The optimal cut-off values for PIV (426.8) and AGR (1.4) were determined using maximally selected rank statistics. Kaplan–Meier analysis showed that patients in the low-PIV group had significantly better 5-year overall survival (OS) compared to the high-PIV group, while those in the high-AGR group had better 5-year OS than those in the low-AGR group. Multivariate analysis identified age, N stage, degree of differentiation, PIV, and AGR as independent prognostic factors for OS. A nomogram for OS was developed and validated, demonstrating robust predictive performance. This study highlights the value of PIV and AGR as reliable indicators for predicting OS in CRC patients, with high PIV and low AGR associated with worse prognosis. Timely interventions may improve patient outcomes. |
| format | Article |
| id | doaj-art-30687bb45d8c4a64b7e7ee5c3809baf0 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Nature Portfolio |
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| series | Scientific Reports |
| spelling | doaj-art-30687bb45d8c4a64b7e7ee5c3809baf02025-08-20T02:25:40ZengNature PortfolioScientific Reports2045-23222025-04-0115111510.1038/s41598-025-96592-5Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancerKejin Li0Yi Chen1Ziyi Zhang2Kuan Wang3Subinur Sulayman4Xiangyue Zeng5Saibihutula Ababaike6Junmin Guan7Zeliang Zhao8Department of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityDepartment of Gastrointestinal Oncology Surgery, Gastroenterology Center, People’s Hospital of Bortala Mongolian Autonomous PrefectureDepartment of Gastrointestinal Surgery, The Affiliated Cancer Hospital of Xinjiang Medical UniversityAbstract This study evaluated the prognostic value of the pan-immune-inflammation value (PIV) combined with the albumin-to-globulin ratio (AGR) for postoperative survival in colorectal cancer (CRC) patients and developed a nomogram for survival prediction. A total of 650 CRC patients who underwent radical surgery were included, with data from one institution used as the training set. The optimal cut-off values for PIV (426.8) and AGR (1.4) were determined using maximally selected rank statistics. Kaplan–Meier analysis showed that patients in the low-PIV group had significantly better 5-year overall survival (OS) compared to the high-PIV group, while those in the high-AGR group had better 5-year OS than those in the low-AGR group. Multivariate analysis identified age, N stage, degree of differentiation, PIV, and AGR as independent prognostic factors for OS. A nomogram for OS was developed and validated, demonstrating robust predictive performance. This study highlights the value of PIV and AGR as reliable indicators for predicting OS in CRC patients, with high PIV and low AGR associated with worse prognosis. Timely interventions may improve patient outcomes.https://doi.org/10.1038/s41598-025-96592-5Colorectal cancerPreoperative immune-inflammatory valuesAlbumin-to‑globulin ratioNomogramPrognosisOverall survival |
| spellingShingle | Kejin Li Yi Chen Ziyi Zhang Kuan Wang Subinur Sulayman Xiangyue Zeng Saibihutula Ababaike Junmin Guan Zeliang Zhao Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer Scientific Reports Colorectal cancer Preoperative immune-inflammatory values Albumin-to‑globulin ratio Nomogram Prognosis Overall survival |
| title | Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer |
| title_full | Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer |
| title_fullStr | Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer |
| title_full_unstemmed | Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer |
| title_short | Preoperative pan-immuno-inflammatory values and albumin-to-globulin ratio predict the prognosis of stage I–III colorectal cancer |
| title_sort | preoperative pan immuno inflammatory values and albumin to globulin ratio predict the prognosis of stage i iii colorectal cancer |
| topic | Colorectal cancer Preoperative immune-inflammatory values Albumin-to‑globulin ratio Nomogram Prognosis Overall survival |
| url | https://doi.org/10.1038/s41598-025-96592-5 |
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