Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies
Parkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson's disease has long been through to...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Parkinson's Disease |
| Online Access: | http://dx.doi.org/10.1155/2012/151039 |
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| author | José M. Bravo-San Pedro Rubén Gómez-Sánchez Elisa Pizarro-Estrella Mireia Niso-Santano Rosa A. González-Polo José M. Fuentes Rodríguez |
| author_facet | José M. Bravo-San Pedro Rubén Gómez-Sánchez Elisa Pizarro-Estrella Mireia Niso-Santano Rosa A. González-Polo José M. Fuentes Rodríguez |
| author_sort | José M. Bravo-San Pedro |
| collection | DOAJ |
| description | Parkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson's disease has long been through to involve both genetic and environmental factors. Mutations in the leucine-rich repeat kinase 2 gene cause late-onset Parkinson's disease with a clinical appearance indistinguishable from Parkinson's disease idiopathic. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damage proteins and cytoplasmic organelles. This degradative process has been associated with cellular dysfunction in neurodegenerative processes including Parkinson's disease. We discuss the role of leucine-rich repeat kinase 2 in autophagy, and how the deregulations of this degradative mechanism in cells can be implicated in the Parkinson's disease etiology. |
| format | Article |
| id | doaj-art-3064859e9b67475ebc3aa47e3d054d97 |
| institution | OA Journals |
| issn | 2090-8083 2042-0080 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Parkinson's Disease |
| spelling | doaj-art-3064859e9b67475ebc3aa47e3d054d972025-08-20T02:07:57ZengWileyParkinson's Disease2090-80832042-00802012-01-01201210.1155/2012/151039151039Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate EnemiesJosé M. Bravo-San Pedro0Rubén Gómez-Sánchez1Elisa Pizarro-Estrella2Mireia Niso-Santano3Rosa A. González-Polo4José M. Fuentes Rodríguez5Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainCentro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Departamento de Bioquímica y Biología Molecular y Genética, E. Enfermería y T.O., Universidad de Extremadura, 10003 Cáceres, SpainParkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson's disease has long been through to involve both genetic and environmental factors. Mutations in the leucine-rich repeat kinase 2 gene cause late-onset Parkinson's disease with a clinical appearance indistinguishable from Parkinson's disease idiopathic. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damage proteins and cytoplasmic organelles. This degradative process has been associated with cellular dysfunction in neurodegenerative processes including Parkinson's disease. We discuss the role of leucine-rich repeat kinase 2 in autophagy, and how the deregulations of this degradative mechanism in cells can be implicated in the Parkinson's disease etiology.http://dx.doi.org/10.1155/2012/151039 |
| spellingShingle | José M. Bravo-San Pedro Rubén Gómez-Sánchez Elisa Pizarro-Estrella Mireia Niso-Santano Rosa A. González-Polo José M. Fuentes Rodríguez Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies Parkinson's Disease |
| title | Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies |
| title_full | Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies |
| title_fullStr | Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies |
| title_full_unstemmed | Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies |
| title_short | Parkinson's Disease: Leucine-Rich Repeat Kinase 2 and Autophagy, Intimate Enemies |
| title_sort | parkinson s disease leucine rich repeat kinase 2 and autophagy intimate enemies |
| url | http://dx.doi.org/10.1155/2012/151039 |
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