Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase

Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active...

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Main Authors: Keiichi Mitsuyama, Nobuo Tomiyasu, Kosuke Takaki, Junya Masuda, Hiroshi Yamasaki, Kotaro Kuwaki, Teiko Takeda, Shigehiko Kitazaki, Osamu Tsuruta, Michio Sata
Format: Article
Language:English
Published: Wiley 2006-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/MI/2006/26875
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author Keiichi Mitsuyama
Nobuo Tomiyasu
Kosuke Takaki
Junya Masuda
Hiroshi Yamasaki
Kotaro Kuwaki
Teiko Takeda
Shigehiko Kitazaki
Osamu Tsuruta
Michio Sata
author_facet Keiichi Mitsuyama
Nobuo Tomiyasu
Kosuke Takaki
Junya Masuda
Hiroshi Yamasaki
Kotaro Kuwaki
Teiko Takeda
Shigehiko Kitazaki
Osamu Tsuruta
Michio Sata
author_sort Keiichi Mitsuyama
collection DOAJ
description Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10 circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is increased during disease recovery in patients with inflammatory bowel disease, and may be a helpful marker in monitoring disease status.
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institution Kabale University
issn 0962-9351
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language English
publishDate 2006-01-01
publisher Wiley
record_format Article
series Mediators of Inflammation
spelling doaj-art-304fba9a4a0041fb942b3739909213892025-02-03T06:12:44ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/2687526875Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery PhaseKeiichi Mitsuyama0Nobuo Tomiyasu1Kosuke Takaki2Junya Masuda3Hiroshi Yamasaki4Kotaro Kuwaki5Teiko Takeda6Shigehiko Kitazaki7Osamu Tsuruta8Michio Sata9Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanUsing a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10 circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is increased during disease recovery in patients with inflammatory bowel disease, and may be a helpful marker in monitoring disease status.http://dx.doi.org/10.1155/MI/2006/26875
spellingShingle Keiichi Mitsuyama
Nobuo Tomiyasu
Kosuke Takaki
Junya Masuda
Hiroshi Yamasaki
Kotaro Kuwaki
Teiko Takeda
Shigehiko Kitazaki
Osamu Tsuruta
Michio Sata
Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
Mediators of Inflammation
title Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
title_full Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
title_fullStr Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
title_full_unstemmed Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
title_short Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
title_sort interleukin 10 in the pathophysiology of inflammatory bowel disease increased serum concentrations during the recovery phase
url http://dx.doi.org/10.1155/MI/2006/26875
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