Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase
Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active...
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Format: | Article |
Language: | English |
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Wiley
2006-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/MI/2006/26875 |
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author | Keiichi Mitsuyama Nobuo Tomiyasu Kosuke Takaki Junya Masuda Hiroshi Yamasaki Kotaro Kuwaki Teiko Takeda Shigehiko Kitazaki Osamu Tsuruta Michio Sata |
author_facet | Keiichi Mitsuyama Nobuo Tomiyasu Kosuke Takaki Junya Masuda Hiroshi Yamasaki Kotaro Kuwaki Teiko Takeda Shigehiko Kitazaki Osamu Tsuruta Michio Sata |
author_sort | Keiichi Mitsuyama |
collection | DOAJ |
description | Using a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with
ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal
control subjects. Serum IL-10 concentrations were increased in patients with
active UC but not in those with active CD when compared with normal control subjects. A time course study
showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein
increased during the acute phase and returned to normal as patients go into remission. Notably,
serum IL-10 concentrations increased during the phase of disease resolution and declined
thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10
circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is
increased during disease recovery in patients with inflammatory bowel disease, and may be a
helpful marker in monitoring disease status. |
format | Article |
id | doaj-art-304fba9a4a0041fb942b373990921389 |
institution | Kabale University |
issn | 0962-9351 1466-1861 |
language | English |
publishDate | 2006-01-01 |
publisher | Wiley |
record_format | Article |
series | Mediators of Inflammation |
spelling | doaj-art-304fba9a4a0041fb942b3739909213892025-02-03T06:12:44ZengWileyMediators of Inflammation0962-93511466-18612006-01-01200610.1155/MI/2006/2687526875Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery PhaseKeiichi Mitsuyama0Nobuo Tomiyasu1Kosuke Takaki2Junya Masuda3Hiroshi Yamasaki4Kotaro Kuwaki5Teiko Takeda6Shigehiko Kitazaki7Osamu Tsuruta8Michio Sata9Division of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanDivision of Gastroenterology, Department of Medicine, Kurume University School of Medicine, Asahi-machi 67, Kurume 830-0011, JapanUsing a specific enzyme-linked immunosorbent assay, IL-10 concentrations were measured in serum from 62 patients with ulcerative colitis (UC), 43 with Crohn's disease (CD), 25 with other colitides, and 44 normal control subjects. Serum IL-10 concentrations were increased in patients with active UC but not in those with active CD when compared with normal control subjects. A time course study showed that in patients with UC and CD, serum concentrations of IL-6 and C-reactive protein increased during the acute phase and returned to normal as patients go into remission. Notably, serum IL-10 concentrations increased during the phase of disease resolution and declined thereafter regardless of the treatment modality. Gel filtration analysis indicated that IL-10 circulated predominantly as a dimer. In conclusion, this study shows that serum IL-10 is increased during disease recovery in patients with inflammatory bowel disease, and may be a helpful marker in monitoring disease status.http://dx.doi.org/10.1155/MI/2006/26875 |
spellingShingle | Keiichi Mitsuyama Nobuo Tomiyasu Kosuke Takaki Junya Masuda Hiroshi Yamasaki Kotaro Kuwaki Teiko Takeda Shigehiko Kitazaki Osamu Tsuruta Michio Sata Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase Mediators of Inflammation |
title | Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase |
title_full | Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase |
title_fullStr | Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase |
title_full_unstemmed | Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase |
title_short | Interleukin-10 in the Pathophysiology of Inflammatory Bowel Disease: Increased Serum Concentrations During the Recovery Phase |
title_sort | interleukin 10 in the pathophysiology of inflammatory bowel disease increased serum concentrations during the recovery phase |
url | http://dx.doi.org/10.1155/MI/2006/26875 |
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