Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk
The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria. Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer’s disease (AD). The...
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| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2126272 |
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| author | Jiangyue Lu Shuang Zhang Yuezhen Huang Jun Qian Baochun Tan Xueshen Qian Jia Zhuang Xihong Zou Yanfen Li Fuhua Yan |
| author_facet | Jiangyue Lu Shuang Zhang Yuezhen Huang Jun Qian Baochun Tan Xueshen Qian Jia Zhuang Xihong Zou Yanfen Li Fuhua Yan |
| author_sort | Jiangyue Lu |
| collection | DOAJ |
| description | The oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria. Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer’s disease (AD). The intestine and central nervous system jointly engage in crosstalk; microbiota-mediated immunity significantly impacts AD via the gut-brain axis. However, the exact mechanism linking periodontitis to AD remains unclear. In this study, we explored the influence of periodontitis-related salivary microbiota on AD based on the gut-brain crosstalk in APPswe/PS1ΔE9 (PAP) transgenic mice. Saliva samples were collected from patients with periodontitis and healthy individuals. The salivary microbiota was gavaged into PAP mice for two months. Continuous gavage of periodontitis-related salivary microbiota in PAP mice impaired cognitive function and increased β-amyloid accumulation and neuroinflammation. Moreover, these AD-related pathologies were consistent with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation, suggesting that the periodontitis-related salivary microbiota may aggravate AD pathogenesis through crosstalk of the gut-brain axis. In this study, we demonstrated that periodontitis might participate in the pathogenesis of AD by swallowing salivary microbiota, verifying the role of periodontitis in AD progression and providing a novel perspective on the etiology and intervention strategies of AD. |
| format | Article |
| id | doaj-art-304d9efb743b4993905ca12a4bc7d0ca |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-304d9efb743b4993905ca12a4bc7d0ca2025-08-20T03:05:25ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2126272Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalkJiangyue Lu0Shuang Zhang1Yuezhen Huang2Jun Qian3Baochun Tan4Xueshen Qian5Jia Zhuang6Xihong Zou7Yanfen Li8Fuhua Yan9Nanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaNanjing Stomatological Hospital, Medical School of Nanjing University, Nanjing, ChinaThe oral cavity is the initial chamber of digestive tract; the saliva swallowed daily contains an estimated 1.5 × 1012 oral bacteria. Increasing evidence indicates that periodontal pathogens and subsequent inflammatory responses to them contribute to the pathogenesis of Alzheimer’s disease (AD). The intestine and central nervous system jointly engage in crosstalk; microbiota-mediated immunity significantly impacts AD via the gut-brain axis. However, the exact mechanism linking periodontitis to AD remains unclear. In this study, we explored the influence of periodontitis-related salivary microbiota on AD based on the gut-brain crosstalk in APPswe/PS1ΔE9 (PAP) transgenic mice. Saliva samples were collected from patients with periodontitis and healthy individuals. The salivary microbiota was gavaged into PAP mice for two months. Continuous gavage of periodontitis-related salivary microbiota in PAP mice impaired cognitive function and increased β-amyloid accumulation and neuroinflammation. Moreover, these AD-related pathologies were consistent with gut microbial dysbiosis, intestinal pro-inflammatory responses, intestinal barrier impairment, and subsequent exacerbation of systemic inflammation, suggesting that the periodontitis-related salivary microbiota may aggravate AD pathogenesis through crosstalk of the gut-brain axis. In this study, we demonstrated that periodontitis might participate in the pathogenesis of AD by swallowing salivary microbiota, verifying the role of periodontitis in AD progression and providing a novel perspective on the etiology and intervention strategies of AD.https://www.tandfonline.com/doi/10.1080/19490976.2022.2126272PeriodontitisAlzheimer’s diseasesalivagut microbiotagut-brain axisinflammation |
| spellingShingle | Jiangyue Lu Shuang Zhang Yuezhen Huang Jun Qian Baochun Tan Xueshen Qian Jia Zhuang Xihong Zou Yanfen Li Fuhua Yan Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk Gut Microbes Periodontitis Alzheimer’s disease saliva gut microbiota gut-brain axis inflammation |
| title | Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk |
| title_full | Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk |
| title_fullStr | Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk |
| title_full_unstemmed | Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk |
| title_short | Periodontitis-related salivary microbiota aggravates Alzheimer’s disease via gut-brain axis crosstalk |
| title_sort | periodontitis related salivary microbiota aggravates alzheimer s disease via gut brain axis crosstalk |
| topic | Periodontitis Alzheimer’s disease saliva gut microbiota gut-brain axis inflammation |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2126272 |
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