A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024
Abstract This study investigates the seroprevalence and trends of Hepatitis C virus (HCV) infection in Thailand in 2024 through a nationwide serosurvey. A cross-sectional study was conducted from May to July 2024, recruiting 6069 participants aged 6 months to 80 years from four provinces representin...
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Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-04578-0 |
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| author | Sitthichai Kanokudom Pornjarim Nilyanimit Jiratchaya Puenpa Nungruthai Suntronwong Duong Hoang Huy Le Lakkhana Wongsrisang Sirapa Klinfueng Prangnapitch Wihanthong Narong Thawinwisan Pichet Puedkuntod Watcharanan Tinnaitorn Pornsawan Meechin Nasamon Wanlapakorn Sittisak Honsawek Yong Poovorawan |
| author_facet | Sitthichai Kanokudom Pornjarim Nilyanimit Jiratchaya Puenpa Nungruthai Suntronwong Duong Hoang Huy Le Lakkhana Wongsrisang Sirapa Klinfueng Prangnapitch Wihanthong Narong Thawinwisan Pichet Puedkuntod Watcharanan Tinnaitorn Pornsawan Meechin Nasamon Wanlapakorn Sittisak Honsawek Yong Poovorawan |
| author_sort | Sitthichai Kanokudom |
| collection | DOAJ |
| description | Abstract This study investigates the seroprevalence and trends of Hepatitis C virus (HCV) infection in Thailand in 2024 through a nationwide serosurvey. A cross-sectional study was conducted from May to July 2024, recruiting 6069 participants aged 6 months to 80 years from four provinces representing Thailand’s geographical regions. Serum samples were tested using the Elecsys® HCV Duo-assay, with confirmatory HCV RT-PCR performed on positive cases. The Elecsys® HCV Duo-assay identified 0.33% (20/6069) of participants as positive; among these, 0.18% were anti-HCV positive, and 0.26% were HCVcAg positive. Notably, seven cases were confirmed positive by RT-PCR. Participants born before 1992 (aged ≥ 32 years) exhibited a significantly higher seroprevalence compared to those aged < 32 years (p < 0.001). Comparative national estimates from 2004, 2014, and 2024 revealed a substantial decline in anti-HCV seroprevalence, from 2.15 to 0.94% and then to 0.56%, particularly among the general population under 40 years old. Correspondingly, HCV viremia gradually declined from 1.00 to 0.39% and subsequently to 0.36%, respectively. Thailand has made significant progress in reducing HCV seroprevalence over the past two decades, attributed to effective preventive measures policies. However, targeted interventions in high-risk and older populations remain essential to achieve the WHO’s goal of HCV elimination by 2030. |
| format | Article |
| id | doaj-art-304a4fd3f5ee4ff28df4989e3429fe12 |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-304a4fd3f5ee4ff28df4989e3429fe122025-08-20T02:05:13ZengNature PortfolioScientific Reports2045-23222025-06-0115111010.1038/s41598-025-04578-0A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024Sitthichai Kanokudom0Pornjarim Nilyanimit1Jiratchaya Puenpa2Nungruthai Suntronwong3Duong Hoang Huy Le4Lakkhana Wongsrisang5Sirapa Klinfueng6Prangnapitch Wihanthong7Narong Thawinwisan8Pichet Puedkuntod9Watcharanan Tinnaitorn10Pornsawan Meechin11Nasamon Wanlapakorn12Sittisak Honsawek13Yong Poovorawan14Department of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityDivision of Epidemiology, Department of Disease Control, Ministry of Public HealthAyutthaya Provincial Health Office, Office of the Permanent Secretary Ministry of Public HealthBuriram Provincial Health Office, Office of the Permanent Secretary Ministry of Public HealthTrang Provincial Public Health Office, Office of the Permanent Secretary Ministry of Public HealthFaktha HospitalDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityFaculty of Medicine, Center of Excellence in Osteoarthritis and Musculoskeleton, , Chulalongkorn University, King Chulalongkorn Memorial Hospital, Thai Red Cross SocietyDepartment of Pediatrics, Faculty of Medicine, Center of Excellence in Clinical Virology, Chulalongkorn UniversityAbstract This study investigates the seroprevalence and trends of Hepatitis C virus (HCV) infection in Thailand in 2024 through a nationwide serosurvey. A cross-sectional study was conducted from May to July 2024, recruiting 6069 participants aged 6 months to 80 years from four provinces representing Thailand’s geographical regions. Serum samples were tested using the Elecsys® HCV Duo-assay, with confirmatory HCV RT-PCR performed on positive cases. The Elecsys® HCV Duo-assay identified 0.33% (20/6069) of participants as positive; among these, 0.18% were anti-HCV positive, and 0.26% were HCVcAg positive. Notably, seven cases were confirmed positive by RT-PCR. Participants born before 1992 (aged ≥ 32 years) exhibited a significantly higher seroprevalence compared to those aged < 32 years (p < 0.001). Comparative national estimates from 2004, 2014, and 2024 revealed a substantial decline in anti-HCV seroprevalence, from 2.15 to 0.94% and then to 0.56%, particularly among the general population under 40 years old. Correspondingly, HCV viremia gradually declined from 1.00 to 0.39% and subsequently to 0.36%, respectively. Thailand has made significant progress in reducing HCV seroprevalence over the past two decades, attributed to effective preventive measures policies. However, targeted interventions in high-risk and older populations remain essential to achieve the WHO’s goal of HCV elimination by 2030.https://doi.org/10.1038/s41598-025-04578-0Hepatitis C eliminationSeroprevalenceThe Elecsys® HCV Duo-assay (Duo-assay)Anti-HCVHCV core antigen (HCVcAg) |
| spellingShingle | Sitthichai Kanokudom Pornjarim Nilyanimit Jiratchaya Puenpa Nungruthai Suntronwong Duong Hoang Huy Le Lakkhana Wongsrisang Sirapa Klinfueng Prangnapitch Wihanthong Narong Thawinwisan Pichet Puedkuntod Watcharanan Tinnaitorn Pornsawan Meechin Nasamon Wanlapakorn Sittisak Honsawek Yong Poovorawan A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 Scientific Reports Hepatitis C elimination Seroprevalence The Elecsys® HCV Duo-assay (Duo-assay) Anti-HCV HCV core antigen (HCVcAg) |
| title | A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 |
| title_full | A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 |
| title_fullStr | A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 |
| title_full_unstemmed | A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 |
| title_short | A comparative national survey on the gradual decline of hepatitis C virus prevalence in Thailand, 2004, 2014, and 2024 |
| title_sort | comparative national survey on the gradual decline of hepatitis c virus prevalence in thailand 2004 2014 and 2024 |
| topic | Hepatitis C elimination Seroprevalence The Elecsys® HCV Duo-assay (Duo-assay) Anti-HCV HCV core antigen (HCVcAg) |
| url | https://doi.org/10.1038/s41598-025-04578-0 |
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