Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation
Malignant infiltration of the liver is a rare cause of acute liver failure and is associated with an exceedingly high mortality rate. We describe the case of an elderly woman presenting with fulminant hepatitis and simultaneous type B lactic acidosis, with near-normal imaging findings, who was later...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SMC MEDIA SRL
2025-03-01
|
| Series: | European Journal of Case Reports in Internal Medicine |
| Subjects: | |
| Online Access: | https://www.ejcrim.com/index.php/EJCRIM/article/view/5236 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849766876095184896 |
|---|---|
| author | Catarina Melita Joaquim Tinoco Rita Theias Manso Liliana Antunes Mónica Palma Anselmo Paulo Telles de Freitas |
| author_facet | Catarina Melita Joaquim Tinoco Rita Theias Manso Liliana Antunes Mónica Palma Anselmo Paulo Telles de Freitas |
| author_sort | Catarina Melita |
| collection | DOAJ |
| description | Malignant infiltration of the liver is a rare cause of acute liver failure and is associated with an exceedingly high mortality rate. We describe the case of an elderly woman presenting with fulminant hepatitis and simultaneous type B lactic acidosis, with near-normal imaging findings, who was later demonstrated to have non-Hodgkin lymphoma. The presence of acute liver failure, hepatomegaly, markedly elevated lactate dehydrogenase and/or lactic acidosis should raise suspicion for lymphoma infiltration of the liver and prompt liver biopsy early in the course of disease. We hope to raise awareness for this uncommon and elusive presentation of lymphoma, in the hope that it will help achieve earlier diagnoses and improvements in patient survival. |
| format | Article |
| id | doaj-art-303fae2834224089bcd96e67fbfebd8e |
| institution | DOAJ |
| issn | 2284-2594 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | SMC MEDIA SRL |
| record_format | Article |
| series | European Journal of Case Reports in Internal Medicine |
| spelling | doaj-art-303fae2834224089bcd96e67fbfebd8e2025-08-20T03:04:26ZengSMC MEDIA SRLEuropean Journal of Case Reports in Internal Medicine2284-25942025-03-0110.12890/2025_0052364771Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentationCatarina Melita0https://orcid.org/0000-0001-7445-7861Joaquim Tinoco1Rita Theias Manso2Liliana Antunes3Mónica Palma Anselmo4Paulo Telles de Freitas5Internal Medicine Department 2, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalSurgical Pathology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalSurgical Pathology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalIntensive Care Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalIntensive Care Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalIntensive Care Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, PortugalMalignant infiltration of the liver is a rare cause of acute liver failure and is associated with an exceedingly high mortality rate. We describe the case of an elderly woman presenting with fulminant hepatitis and simultaneous type B lactic acidosis, with near-normal imaging findings, who was later demonstrated to have non-Hodgkin lymphoma. The presence of acute liver failure, hepatomegaly, markedly elevated lactate dehydrogenase and/or lactic acidosis should raise suspicion for lymphoma infiltration of the liver and prompt liver biopsy early in the course of disease. We hope to raise awareness for this uncommon and elusive presentation of lymphoma, in the hope that it will help achieve earlier diagnoses and improvements in patient survival.https://www.ejcrim.com/index.php/EJCRIM/article/view/5236acute liver failurelactic acidosisnon-hodgkin lymphomafulminant hepatitishepatic malignant infiltration |
| spellingShingle | Catarina Melita Joaquim Tinoco Rita Theias Manso Liliana Antunes Mónica Palma Anselmo Paulo Telles de Freitas Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation European Journal of Case Reports in Internal Medicine acute liver failure lactic acidosis non-hodgkin lymphoma fulminant hepatitis hepatic malignant infiltration |
| title | Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation |
| title_full | Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation |
| title_fullStr | Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation |
| title_full_unstemmed | Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation |
| title_short | Malignancy can present as acute liver failure – a case report of B-cell lymphoma with acute liver failure as its first presentation |
| title_sort | malignancy can present as acute liver failure a case report of b cell lymphoma with acute liver failure as its first presentation |
| topic | acute liver failure lactic acidosis non-hodgkin lymphoma fulminant hepatitis hepatic malignant infiltration |
| url | https://www.ejcrim.com/index.php/EJCRIM/article/view/5236 |
| work_keys_str_mv | AT catarinamelita malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation AT joaquimtinoco malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation AT ritatheiasmanso malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation AT lilianaantunes malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation AT monicapalmaanselmo malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation AT paulotellesdefreitas malignancycanpresentasacuteliverfailureacasereportofbcelllymphomawithacuteliverfailureasitsfirstpresentation |