Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime
Abstract Cancer treatment is often ineffective due to poor bioimaging and resistance to standard therapies. This issue is exacerbated by multiple low‐penetrable bio‐barriers that limit the theranostic agents’ effectiveness in tumors. Here, a hollow nanomotor PM‐HMSN/Arg is fabricated by a sequential...
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| Format: | Article |
| Language: | English |
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Wiley
2025-08-01
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| Series: | Advanced Science |
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| Online Access: | https://doi.org/10.1002/advs.202416709 |
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| author | Xue Xu Jinxu Cao Yan Mu Hao Zhang Ya‐Lei Wang Mengzhen Chen Yuce Li Qian Hua |
| author_facet | Xue Xu Jinxu Cao Yan Mu Hao Zhang Ya‐Lei Wang Mengzhen Chen Yuce Li Qian Hua |
| author_sort | Xue Xu |
| collection | DOAJ |
| description | Abstract Cancer treatment is often ineffective due to poor bioimaging and resistance to standard therapies. This issue is exacerbated by multiple low‐penetrable bio‐barriers that limit the theranostic agents’ effectiveness in tumors. Here, a hollow nanomotor PM‐HMSN/Arg is fabricated by a sequential process involving: electrostatic adsorption of Mn2+, loading of l‐Arg, and coating of platelet membrane (PM), respectively. This nanomotor uses l‐Arg as an NO donor and ultrasound (US) as a trigger for NO release. After administration, it improves tumor penetration via a “tethering‐relaxing‐drilling” mechanism, overcoming bio‐barriers during delivery from blood vessels to tumor cells. NO regulates the metabolism of tumor vascular endothelial cells, facilitating relaxation, and enhances cytotoxicity by participating in reactive oxygen species metabolism. More importantly, the nanomotor's active motion enhances tissue penetration and retention in cancer, increasing therapeutic effects. In addition, continuous in situ NO generation extends US imaging signal lifetime. This innovative nanomotor shows promise for multimodal theranostics in low‐penetrable tumors. |
| format | Article |
| id | doaj-art-303c853177734b5d899e6af45a8c591e |
| institution | Kabale University |
| issn | 2198-3844 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-303c853177734b5d899e6af45a8c591e2025-08-20T11:56:10ZengWileyAdvanced Science2198-38442025-08-011230n/an/a10.1002/advs.202416709Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended LifetimeXue Xu0Jinxu Cao1Yan Mu2Hao Zhang3Ya‐Lei Wang4Mengzhen Chen5Yuce Li6Qian Hua7School of Medicine Wuhan University of Science and Technology Wuhan 430065 ChinaSchool of Medicine Wuhan University of Science and Technology Wuhan 430065 ChinaSchool of Life Sciences School of Chinese Medicine Beijing University of Chinese medicine Beijing 100029 ChinaSchool of Life Sciences School of Chinese Medicine Beijing University of Chinese medicine Beijing 100029 ChinaSchool of Life Sciences School of Chinese Medicine Beijing University of Chinese medicine Beijing 100029 ChinaSchool of Medicine Wuhan University of Science and Technology Wuhan 430065 ChinaCollege of Life Sciences and Health Wuhan University of Science and Technology Wuhan 430065 ChinaSchool of Life Sciences School of Chinese Medicine Beijing University of Chinese medicine Beijing 100029 ChinaAbstract Cancer treatment is often ineffective due to poor bioimaging and resistance to standard therapies. This issue is exacerbated by multiple low‐penetrable bio‐barriers that limit the theranostic agents’ effectiveness in tumors. Here, a hollow nanomotor PM‐HMSN/Arg is fabricated by a sequential process involving: electrostatic adsorption of Mn2+, loading of l‐Arg, and coating of platelet membrane (PM), respectively. This nanomotor uses l‐Arg as an NO donor and ultrasound (US) as a trigger for NO release. After administration, it improves tumor penetration via a “tethering‐relaxing‐drilling” mechanism, overcoming bio‐barriers during delivery from blood vessels to tumor cells. NO regulates the metabolism of tumor vascular endothelial cells, facilitating relaxation, and enhances cytotoxicity by participating in reactive oxygen species metabolism. More importantly, the nanomotor's active motion enhances tissue penetration and retention in cancer, increasing therapeutic effects. In addition, continuous in situ NO generation extends US imaging signal lifetime. This innovative nanomotor shows promise for multimodal theranostics in low‐penetrable tumors.https://doi.org/10.1002/advs.202416709nanomotornitric oxide therapytumor penetrationultrasonic bioimaging |
| spellingShingle | Xue Xu Jinxu Cao Yan Mu Hao Zhang Ya‐Lei Wang Mengzhen Chen Yuce Li Qian Hua Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime Advanced Science nanomotor nitric oxide therapy tumor penetration ultrasonic bioimaging |
| title | Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime |
| title_full | Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime |
| title_fullStr | Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime |
| title_full_unstemmed | Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime |
| title_short | Ultrasound‐Induced Nitric Oxide‐Propelled Nanomotor for Multimodal Theranostics of Cancer with Deep Penetration and Extended Lifetime |
| title_sort | ultrasound induced nitric oxide propelled nanomotor for multimodal theranostics of cancer with deep penetration and extended lifetime |
| topic | nanomotor nitric oxide therapy tumor penetration ultrasonic bioimaging |
| url | https://doi.org/10.1002/advs.202416709 |
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