Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin
For any physician, fever of unknown origin (FUO) is an enigmatic problem, while being equally frustrating. It tests the limits of patience of both the physician and the patient. While the majority of such cases end up being of infective etiology, the rest are attributable to noninfectious inflammato...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2019-10-01
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| Series: | Indian Journal of Medical Specialities |
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| Online Access: | https://journals.lww.com/10.4103/INJMS.INJMS_66_19 |
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| author | Ashutosh Garg Vivek Pal Singh Jai Khullar Afreen Khan |
| author_facet | Ashutosh Garg Vivek Pal Singh Jai Khullar Afreen Khan |
| author_sort | Ashutosh Garg |
| collection | DOAJ |
| description | For any physician, fever of unknown origin (FUO) is an enigmatic problem, while being equally frustrating. It tests the limits of patience of both the physician and the patient. While the majority of such cases end up being of infective etiology, the rest are attributable to noninfectious inflammatory disorders (NIIDs) and neoplasms. Among the NIIDs, most turn out to be connective tissue disorders (CTDs). CTDs are commonly known to have granulomas on histopathology. However, hepatic granulomas are rarely encountered. We present a case of FUO in an elderly urban North Indian businessman who after thorough workup was diagnosed with idiopathic hepatic granulomatous disease. Response to disease-modifying therapy was rewarding. |
| format | Article |
| id | doaj-art-3031f29e3e444ab2bc832c8137d99152 |
| institution | Kabale University |
| issn | 0976-2884 0976-2892 |
| language | English |
| publishDate | 2019-10-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Medical Specialities |
| spelling | doaj-art-3031f29e3e444ab2bc832c8137d991522025-08-25T08:31:31ZengWolters Kluwer Medknow PublicationsIndian Journal of Medical Specialities0976-28840976-28922019-10-0110422522810.4103/INJMS.INJMS_66_19Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown OriginAshutosh GargVivek Pal SinghJai KhullarAfreen KhanFor any physician, fever of unknown origin (FUO) is an enigmatic problem, while being equally frustrating. It tests the limits of patience of both the physician and the patient. While the majority of such cases end up being of infective etiology, the rest are attributable to noninfectious inflammatory disorders (NIIDs) and neoplasms. Among the NIIDs, most turn out to be connective tissue disorders (CTDs). CTDs are commonly known to have granulomas on histopathology. However, hepatic granulomas are rarely encountered. We present a case of FUO in an elderly urban North Indian businessman who after thorough workup was diagnosed with idiopathic hepatic granulomatous disease. Response to disease-modifying therapy was rewarding.https://journals.lww.com/10.4103/INJMS.INJMS_66_19disease-modifying drugsfever of unknown origingranulomaliver biopsy |
| spellingShingle | Ashutosh Garg Vivek Pal Singh Jai Khullar Afreen Khan Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin Indian Journal of Medical Specialities disease-modifying drugs fever of unknown origin granuloma liver biopsy |
| title | Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin |
| title_full | Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin |
| title_fullStr | Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin |
| title_full_unstemmed | Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin |
| title_short | Idiopathic Hepatic Granulomatosis: A Challenging Case of Fever of Unknown Origin |
| title_sort | idiopathic hepatic granulomatosis a challenging case of fever of unknown origin |
| topic | disease-modifying drugs fever of unknown origin granuloma liver biopsy |
| url | https://journals.lww.com/10.4103/INJMS.INJMS_66_19 |
| work_keys_str_mv | AT ashutoshgarg idiopathichepaticgranulomatosisachallengingcaseoffeverofunknownorigin AT vivekpalsingh idiopathichepaticgranulomatosisachallengingcaseoffeverofunknownorigin AT jaikhullar idiopathichepaticgranulomatosisachallengingcaseoffeverofunknownorigin AT afreenkhan idiopathichepaticgranulomatosisachallengingcaseoffeverofunknownorigin |