Epigenetic Modifiers to Treat Retinal Degenerative Diseases

Epigenetic Modifiers to Treat Retinal Degenerative Diseases

We have previously demonstrated the ability of inhibitors of LSD1 and HDAC1 to block rod degeneration, preserve vision, maintain transcription of rod photoreceptor genes, and downregulate transcripts involved in cell death, gliosis, and inflammation in the mouse model of Retinitis Pigmentosa (RP), r...

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Bibliographic Details
Main Authors: Evgenya Y. Popova, Lisa Schneper, Aswathy Sebastian, Istvan Albert, Joyce Tombran-Tink, Colin J. Barnstable
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Cells
Subjects:
retina degeneration
chromatin
epigenetic
rod photoreceptor
Online Access:https://www.mdpi.com/2073-4409/14/13/961
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