Unsymmetrical Bisacridines’ Interactions with ABC Transporters and Their Cellular Impact on Colon LS 174T and Prostate DU 145 Cancer Cells

Unsymmetrical Bisacridines’ Interactions with ABC Transporters and Their Cellular Impact on Colon LS 174T and Prostate DU 145 Cancer Cells

Multidrug resistance (MDR) is a process that constitutes a significant obstacle to effective anticancer therapy. Here, we examined whether unsymmetrical bisacridines (UAs) are substrates for ABC transporters and can influence their expression in human colon LS 174T and prostate DU 145 cancer cells....

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Bibliographic Details
Main Authors: Monika Pawłowska, Jolanta Kulesza, Ewa Paluszkiewicz, Ewa Augustin, Zofia Mazerska
Format: Article
Language:English
Published: MDPI AG 2024-11-01
Series:Molecules
Subjects:
anticancer agents
unsymmetrical bisacridines
ABC transporters
multidrug resistance (MDR)
cytotoxicity
cellular response
Online Access:https://www.mdpi.com/1420-3049/29/23/5582
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