Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids
The paper deals with directed synthesis and study of hypoglycemic activity of N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2- butenoic and 4-aryl-3-bromo-2, 4-dioxobutanoic acids. Hypoglycemic activity of 28 compounds was under research. Some regularities of the influence of the heterocyclic moiety str...
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| Format: | Article |
| Language: | English |
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Siberian State Medical University (Tomsk)
2011-10-01
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| Series: | Бюллетень сибирской медицины |
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| Online Access: | https://bulletin.ssmu.ru/jour/article/view/1473 |
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| author | N. A. Pulina A. I. Krasnova F. V. Sobin T. A. Yushkova V. V. Yushkov |
| author_facet | N. A. Pulina A. I. Krasnova F. V. Sobin T. A. Yushkova V. V. Yushkov |
| author_sort | N. A. Pulina |
| collection | DOAJ |
| description | The paper deals with directed synthesis and study of hypoglycemic activity of N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2- butenoic and 4-aryl-3-bromo-2, 4-dioxobutanoic acids. Hypoglycemic activity of 28 compounds was under research. Some regularities of the influence of the heterocyclic moiety structure and the bromine atom on the activity of the compounds were obtained. Two low-toxic and highly active substances comparable in potency with the reference drug were identified. |
| format | Article |
| id | doaj-art-30245ddc50f748098b28bf8401caba3d |
| institution | DOAJ |
| issn | 1682-0363 1819-3684 |
| language | English |
| publishDate | 2011-10-01 |
| publisher | Siberian State Medical University (Tomsk) |
| record_format | Article |
| series | Бюллетень сибирской медицины |
| spelling | doaj-art-30245ddc50f748098b28bf8401caba3d2025-08-20T03:02:23ZengSiberian State Medical University (Tomsk)Бюллетень сибирской медицины1682-03631819-36842011-10-01105869010.20538/1682-0363-2011-5-86-90979Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acidsN. A. Pulina0A. I. Krasnova1F. V. Sobin2T. A. Yushkova3V. V. Yushkov4Пермская государственная фармацевтическая академияПермская государственная фармацевтическая академияПермская государственная фармацевтическая академияПермская государственная фармацевтическая академияПермская государственная фармацевтическая академияThe paper deals with directed synthesis and study of hypoglycemic activity of N-heterylamides of 4-aryl-2-hydroxy-4-oxo-2- butenoic and 4-aryl-3-bromo-2, 4-dioxobutanoic acids. Hypoglycemic activity of 28 compounds was under research. Some regularities of the influence of the heterocyclic moiety structure and the bromine atom on the activity of the compounds were obtained. Two low-toxic and highly active substances comparable in potency with the reference drug were identified.https://bulletin.ssmu.ru/jour/article/view/1473n-heterylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acidshypoglycemic activity |
| spellingShingle | N. A. Pulina A. I. Krasnova F. V. Sobin T. A. Yushkova V. V. Yushkov Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids Бюллетень сибирской медицины n-heterylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids hypoglycemic activity |
| title | Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids |
| title_full | Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids |
| title_fullStr | Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids |
| title_full_unstemmed | Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids |
| title_short | Directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids |
| title_sort | directed synthesis and search of pharmaceutical substances with hypoglycemic activity in the series of 4 aryl 2 hydroxy 4 oxo 2 butenoic acids |
| topic | n-heterylamides of 4-aryl-2-hydroxy-4-oxo-2-butenoic acids hypoglycemic activity |
| url | https://bulletin.ssmu.ru/jour/article/view/1473 |
| work_keys_str_mv | AT napulina directedsynthesisandsearchofpharmaceuticalsubstanceswithhypoglycemicactivityintheseriesof4aryl2hydroxy4oxo2butenoicacids AT aikrasnova directedsynthesisandsearchofpharmaceuticalsubstanceswithhypoglycemicactivityintheseriesof4aryl2hydroxy4oxo2butenoicacids AT fvsobin directedsynthesisandsearchofpharmaceuticalsubstanceswithhypoglycemicactivityintheseriesof4aryl2hydroxy4oxo2butenoicacids AT tayushkova directedsynthesisandsearchofpharmaceuticalsubstanceswithhypoglycemicactivityintheseriesof4aryl2hydroxy4oxo2butenoicacids AT vvyushkov directedsynthesisandsearchofpharmaceuticalsubstanceswithhypoglycemicactivityintheseriesof4aryl2hydroxy4oxo2butenoicacids |