Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications
Photothermal therapy (PTT) offers revolutionary breakthroughs in tumor treatment due to its minimally invasive nature, high selectivity and efficiency. Photothermal therapy is a method of using laser irradiation (near-infrared light) to convert light energy into heat, reaching a relatively high temp...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-07-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1604965/full |
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| author | Xiaoling Han Guohai Feng Xiaoman Li Shuyi Mo Caijing Xu Jiahui Yan Li Yu Rong Zhang Ying Jin Xiao Xiao Li Deng |
| author_facet | Xiaoling Han Guohai Feng Xiaoman Li Shuyi Mo Caijing Xu Jiahui Yan Li Yu Rong Zhang Ying Jin Xiao Xiao Li Deng |
| author_sort | Xiaoling Han |
| collection | DOAJ |
| description | Photothermal therapy (PTT) offers revolutionary breakthroughs in tumor treatment due to its minimally invasive nature, high selectivity and efficiency. Photothermal therapy is a method of using laser irradiation (near-infrared light) to convert light energy into heat, reaching a relatively high temperature to kill tumor cells. Efficient and stable photothermal conversion materials are the key factors in PTT. There are inorganic and organic nanomaterials used in photothermal therapy. Through chemical modification of them, the functions of targeted drug delivery and combination therapy can be achieved. This work generalizes the features, excellent performance and therapeutic effects of photothermal conversion nanomaterials such as polydopamine (PDA), semiconductor nanoparticles (SNPs), Au nanomaterials, palladium nanosheets (PdNs), and carbon nanomaterials. Their functions and the advantages in photothermal therapy, tumor targeting and inactivation, and the mechanisms of nanophotothermal therapy are summarized. By continuously improving the performance and treatment methods of nanomaterials, more efficient, safe and minimally invasive solutions for tumor treatment are expected. |
| format | Article |
| id | doaj-art-301dede973b74979875a56a31cc39556 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj-art-301dede973b74979875a56a31cc395562025-08-20T02:37:18ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-07-011610.3389/fphar.2025.16049651604965Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applicationsXiaoling Han0Guohai Feng1Xiaoman Li2Shuyi Mo3Caijing Xu4Jiahui Yan5Li Yu6Rong Zhang7Ying Jin8Xiao Xiao9Li Deng10Department of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Medical Examination, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Medical Examination, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Pharmacy, Jilin Medical University, Jilin, ChinaDepartment of Cardiovascular Surgery, Gaozhou People’s Hospital, Gaozhou, ChinaPhotothermal therapy (PTT) offers revolutionary breakthroughs in tumor treatment due to its minimally invasive nature, high selectivity and efficiency. Photothermal therapy is a method of using laser irradiation (near-infrared light) to convert light energy into heat, reaching a relatively high temperature to kill tumor cells. Efficient and stable photothermal conversion materials are the key factors in PTT. There are inorganic and organic nanomaterials used in photothermal therapy. Through chemical modification of them, the functions of targeted drug delivery and combination therapy can be achieved. This work generalizes the features, excellent performance and therapeutic effects of photothermal conversion nanomaterials such as polydopamine (PDA), semiconductor nanoparticles (SNPs), Au nanomaterials, palladium nanosheets (PdNs), and carbon nanomaterials. Their functions and the advantages in photothermal therapy, tumor targeting and inactivation, and the mechanisms of nanophotothermal therapy are summarized. By continuously improving the performance and treatment methods of nanomaterials, more efficient, safe and minimally invasive solutions for tumor treatment are expected.https://www.frontiersin.org/articles/10.3389/fphar.2025.1604965/fullnanomaterialpolymer nanoparticlesnanophotothermal agentphotothermal therapytumor therapy |
| spellingShingle | Xiaoling Han Guohai Feng Xiaoman Li Shuyi Mo Caijing Xu Jiahui Yan Li Yu Rong Zhang Ying Jin Xiao Xiao Li Deng Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications Frontiers in Pharmacology nanomaterial polymer nanoparticles nanophotothermal agent photothermal therapy tumor therapy |
| title | Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications |
| title_full | Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications |
| title_fullStr | Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications |
| title_full_unstemmed | Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications |
| title_short | Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications |
| title_sort | functional nanomaterials for enhanced tumor photothermal therapy the mechanisms and applications |
| topic | nanomaterial polymer nanoparticles nanophotothermal agent photothermal therapy tumor therapy |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1604965/full |
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