Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions
Inherited cardiac arrhythmias, which may lead to sudden cardiac death, represent a significant health risk, with genetic factors playing a key role in their development. The ankyrin 2 (ANK2) gene, encoding ankyrin-B, is implicated in several heritable arrhythmia syndromes. ANK2 variants have been li...
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| Format: | Article |
| Language: | English |
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IMR Press
2025-01-01
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| Series: | Reviews in Cardiovascular Medicine |
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| Online Access: | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM26013 |
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| author | Linjuan Guo Dexi Wu Wengen Zhu |
| author_facet | Linjuan Guo Dexi Wu Wengen Zhu |
| author_sort | Linjuan Guo |
| collection | DOAJ |
| description | Inherited cardiac arrhythmias, which may lead to sudden cardiac death, represent a significant health risk, with genetic factors playing a key role in their development. The ankyrin 2 (ANK2) gene, encoding ankyrin-B, is implicated in several heritable arrhythmia syndromes. ANK2 variants have been linked to an inherited condition known as “ankyrin-B syndrome”, which manifests as a spectrum of cardiac arrhythmias and cardiomyopathy. Our current review examines the relationship between ANK2 variants and specific heart conditions, summarizing recent findings on the genetic and molecular mechanisms underlying ANK2-related arrhythmias and structural abnormalities. By emphasizing the need for further research, this review aims to enhance understanding of ANK2’s role in heart disease and guide the development of effective therapies. |
| format | Article |
| id | doaj-art-300fc11e9cff4384a81b0718a205d9ba |
| institution | Kabale University |
| issn | 1530-6550 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj-art-300fc11e9cff4384a81b0718a205d9ba2025-01-25T10:41:20ZengIMR PressReviews in Cardiovascular Medicine1530-65502025-01-012612601310.31083/RCM26013S1530-6550(24)01679-XReappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future DirectionsLinjuan Guo0Dexi Wu1Wengen Zhu2Department of Cardiology, Jiangxi Provincial People's Hospital, The First Affiliated Hospital of Nanchang Medical College, 330006 Nanchang, Jiangxi, ChinaDepartment of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, 510080 Guangzhou, Guangdong, ChinaDepartment of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, 510080 Guangzhou, Guangdong, ChinaInherited cardiac arrhythmias, which may lead to sudden cardiac death, represent a significant health risk, with genetic factors playing a key role in their development. The ankyrin 2 (ANK2) gene, encoding ankyrin-B, is implicated in several heritable arrhythmia syndromes. ANK2 variants have been linked to an inherited condition known as “ankyrin-B syndrome”, which manifests as a spectrum of cardiac arrhythmias and cardiomyopathy. Our current review examines the relationship between ANK2 variants and specific heart conditions, summarizing recent findings on the genetic and molecular mechanisms underlying ANK2-related arrhythmias and structural abnormalities. By emphasizing the need for further research, this review aims to enhance understanding of ANK2’s role in heart disease and guide the development of effective therapies.https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM26013ank2ankyrin-bcardiac arrhythmiascardiomyopathymechanism |
| spellingShingle | Linjuan Guo Dexi Wu Wengen Zhu Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions Reviews in Cardiovascular Medicine ank2 ankyrin-b cardiac arrhythmias cardiomyopathy mechanism |
| title | Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions |
| title_full | Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions |
| title_fullStr | Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions |
| title_full_unstemmed | Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions |
| title_short | Reappraisal of ANK2 Variants in Cardiovascular Diseases: Uncovering Mechanisms and Future Directions |
| title_sort | reappraisal of ank2 variants in cardiovascular diseases uncovering mechanisms and future directions |
| topic | ank2 ankyrin-b cardiac arrhythmias cardiomyopathy mechanism |
| url | https://www.imrpress.com/journal/RCM/26/1/10.31083/RCM26013 |
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