Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation
Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a widely used treatment for a variety of hematopoietic disorders, and also provides a valuable platform for investigating the development of donor‐derived immune cells in recipients post‐HSCT. The immune system remodels from...
Saved in:
| Main Authors: | , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2024-10-01
|
| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202400544 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850206748029222912 |
|---|---|
| author | Huidong Guo Liping Guo Bixia Wang Xinya Jiang Zhigui Wu Xiao‐Dong Mo Yu‐Qian Sun Yuan‐Yuan Zhang Zhi‐Dong Wang Jun Kong Chen‐Hua Yan Xiao‐Jun Huang |
| author_facet | Huidong Guo Liping Guo Bixia Wang Xinya Jiang Zhigui Wu Xiao‐Dong Mo Yu‐Qian Sun Yuan‐Yuan Zhang Zhi‐Dong Wang Jun Kong Chen‐Hua Yan Xiao‐Jun Huang |
| author_sort | Huidong Guo |
| collection | DOAJ |
| description | Abstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a widely used treatment for a variety of hematopoietic disorders, and also provides a valuable platform for investigating the development of donor‐derived immune cells in recipients post‐HSCT. The immune system remodels from the donor to the recipient during allo‐HSCT. However, little is known about the cell profile alterations as donor homeostasis rebalances to recipient homeostasis following HSCT. Here, multi‐omics technology is applied at both the single cell and bulk sample levels, as well as spectrum flow cytometry and fluorescent transgenic mouse models, to dissect the dynamics of the rebalanced homeostatic immune system in recipients after allo‐HSCT. The data reveal that all immune subpopulations observed in donors are successfully restored in recipients, though with varying levels of abundance. The remodeling of immune homeostasis exhibits different patterns in HLA‐matched and haploidentical HSCT, highlighting distinct biases in T cell reconstitution from the central and peripheral pathways. Furthermore, ZNF683 is critical for maintaining the persistence and quiescence of CD8 T‐cell in haploidentical HSCT. The research can serve as a foundation for developing novel strategies to induce immune tolerance. |
| format | Article |
| id | doaj-art-2ffdbc9ed3464a97b8aebab9b894ef35 |
| institution | OA Journals |
| issn | 2198-3844 |
| language | English |
| publishDate | 2024-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj-art-2ffdbc9ed3464a97b8aebab9b894ef352025-08-20T02:10:42ZengWileyAdvanced Science2198-38442024-10-011139n/an/a10.1002/advs.202400544Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical TransplantationHuidong Guo0Liping Guo1Bixia Wang2Xinya Jiang3Zhigui Wu4Xiao‐Dong Mo5Yu‐Qian Sun6Yuan‐Yuan Zhang7Zhi‐Dong Wang8Jun Kong9Chen‐Hua Yan10Xiao‐Jun Huang11National Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaNational Clinical Research Center for Hematologic Disease Beijing Key Laboratory of Hematopoietic Stem Cell Transplantation Peking University People's Hospital Peking University Institute of Hematology Peking University Beijing 100044 ChinaAbstract Allogeneic hematopoietic stem cell transplantation (allo‐HSCT) is a widely used treatment for a variety of hematopoietic disorders, and also provides a valuable platform for investigating the development of donor‐derived immune cells in recipients post‐HSCT. The immune system remodels from the donor to the recipient during allo‐HSCT. However, little is known about the cell profile alterations as donor homeostasis rebalances to recipient homeostasis following HSCT. Here, multi‐omics technology is applied at both the single cell and bulk sample levels, as well as spectrum flow cytometry and fluorescent transgenic mouse models, to dissect the dynamics of the rebalanced homeostatic immune system in recipients after allo‐HSCT. The data reveal that all immune subpopulations observed in donors are successfully restored in recipients, though with varying levels of abundance. The remodeling of immune homeostasis exhibits different patterns in HLA‐matched and haploidentical HSCT, highlighting distinct biases in T cell reconstitution from the central and peripheral pathways. Furthermore, ZNF683 is critical for maintaining the persistence and quiescence of CD8 T‐cell in haploidentical HSCT. The research can serve as a foundation for developing novel strategies to induce immune tolerance.https://doi.org/10.1002/advs.202400544allogeneic hematopoietic stem cell transplantationimmune homeostasisimmune reconstitutionimmune toleranceZNF683 |
| spellingShingle | Huidong Guo Liping Guo Bixia Wang Xinya Jiang Zhigui Wu Xiao‐Dong Mo Yu‐Qian Sun Yuan‐Yuan Zhang Zhi‐Dong Wang Jun Kong Chen‐Hua Yan Xiao‐Jun Huang Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation Advanced Science allogeneic hematopoietic stem cell transplantation immune homeostasis immune reconstitution immune tolerance ZNF683 |
| title | Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation |
| title_full | Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation |
| title_fullStr | Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation |
| title_full_unstemmed | Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation |
| title_short | Distinct Immune Homeostasis Remodeling Patterns after HLA‐Matched and Haploidentical Transplantation |
| title_sort | distinct immune homeostasis remodeling patterns after hla matched and haploidentical transplantation |
| topic | allogeneic hematopoietic stem cell transplantation immune homeostasis immune reconstitution immune tolerance ZNF683 |
| url | https://doi.org/10.1002/advs.202400544 |
| work_keys_str_mv | AT huidongguo distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT lipingguo distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT bixiawang distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT xinyajiang distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT zhiguiwu distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT xiaodongmo distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT yuqiansun distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT yuanyuanzhang distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT zhidongwang distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT junkong distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT chenhuayan distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation AT xiaojunhuang distinctimmunehomeostasisremodelingpatternsafterhlamatchedandhaploidenticaltransplantation |