Gene Profiling of Aortic Valve Interstitial Cells under Elevated Pressure Conditions: Modulation of Inflammatory Gene Networks

The study aimed to identify mechanosensitive pathways and gene networks that are stimulated by elevated cyclic pressure in aortic valve interstitial cells (VICs) and lead to detrimental tissue remodeling and/or pathogenesis. Porcine aortic valve leaflets were exposed to cyclic pressures of 80 or 120...

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Bibliographic Details
Main Authors: James N. Warnock, Bindu Nanduri, Carol A. Pregonero Gamez, Juliet Tang, Daniel Koback, William M. Muir, Shane C. Burgess
Format: Article
Language:English
Published: Wiley 2011-01-01
Series:International Journal of Inflammation
Online Access:http://dx.doi.org/10.4061/2011/176412
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