The Volatolome of Chromhidrosis
This study investigates the volatolome in an individual with chromhidrosis, utilizing solid-phase microextraction (SPME) and pentane extraction, followed by gas chromatography–mass spectrometry (GC-MS), to identify key volatile organic compounds (VOCs). A total of 31 compounds were identified, inclu...
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MDPI AG
2024-11-01
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| Online Access: | https://www.mdpi.com/2297-8739/11/11/313 |
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| author | Mila Radan Anđela Plavčić |
| author_facet | Mila Radan Anđela Plavčić |
| author_sort | Mila Radan |
| collection | DOAJ |
| description | This study investigates the volatolome in an individual with chromhidrosis, utilizing solid-phase microextraction (SPME) and pentane extraction, followed by gas chromatography–mass spectrometry (GC-MS), to identify key volatile organic compounds (VOCs). A total of 31 compounds were identified, including aldehydes, fatty acid esters, and benzoic acid derivatives. SPME was more effective in capturing highly volatile compounds, while pentane extraction primarily isolated lipophilic substances such as squalene and cholesterol. The findings suggest that lipid peroxidation and metabolic dysregulation contribute to the formation of lipofuscin, the pigment responsible for colored sweat. Additionally, the detection of 9-octadecenamide and benzoic acid derivatives highlights the role of oxidative processes in chromhidrosis. |
| format | Article |
| id | doaj-art-2ffa18d30bbc45e69c8257d57b57820d |
| institution | OA Journals |
| issn | 2297-8739 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Separations |
| spelling | doaj-art-2ffa18d30bbc45e69c8257d57b57820d2025-08-20T02:27:39ZengMDPI AGSeparations2297-87392024-11-01111131310.3390/separations11110313The Volatolome of ChromhidrosisMila Radan0Anđela Plavčić1Department of Biochemistry, Faculty of Chemistry and Technology, University of Split, 21000 Split, CroatiaDepartment of Biochemistry, Faculty of Chemistry and Technology, University of Split, 21000 Split, CroatiaThis study investigates the volatolome in an individual with chromhidrosis, utilizing solid-phase microextraction (SPME) and pentane extraction, followed by gas chromatography–mass spectrometry (GC-MS), to identify key volatile organic compounds (VOCs). A total of 31 compounds were identified, including aldehydes, fatty acid esters, and benzoic acid derivatives. SPME was more effective in capturing highly volatile compounds, while pentane extraction primarily isolated lipophilic substances such as squalene and cholesterol. The findings suggest that lipid peroxidation and metabolic dysregulation contribute to the formation of lipofuscin, the pigment responsible for colored sweat. Additionally, the detection of 9-octadecenamide and benzoic acid derivatives highlights the role of oxidative processes in chromhidrosis.https://www.mdpi.com/2297-8739/11/11/313chromhidrosisgas chromatography–mass spectrometry (GC-MS)solid-phase microextraction (SPME)sweatlipofuscinvolatile compounds (VOCs) |
| spellingShingle | Mila Radan Anđela Plavčić The Volatolome of Chromhidrosis Separations chromhidrosis gas chromatography–mass spectrometry (GC-MS) solid-phase microextraction (SPME) sweat lipofuscin volatile compounds (VOCs) |
| title | The Volatolome of Chromhidrosis |
| title_full | The Volatolome of Chromhidrosis |
| title_fullStr | The Volatolome of Chromhidrosis |
| title_full_unstemmed | The Volatolome of Chromhidrosis |
| title_short | The Volatolome of Chromhidrosis |
| title_sort | volatolome of chromhidrosis |
| topic | chromhidrosis gas chromatography–mass spectrometry (GC-MS) solid-phase microextraction (SPME) sweat lipofuscin volatile compounds (VOCs) |
| url | https://www.mdpi.com/2297-8739/11/11/313 |
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