Refined methodology for quantifying Pseudomonas aeruginosa virulence using Galleria mellonella

Refined methodology for quantifying Pseudomonas aeruginosa virulence using Galleria mellonella

ABSTRACT Larvae of Galleria mellonella (the greater wax moth) are being increasingly used as a model to study microbial pathogenesis. In this model, bacterial virulence is typically measured by determining the 50% lethal dose (LD50) of a bacterial strain or mutant. The use of G. mellonella to study...

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Main Authors: Christopher M. R. Axline, Travis J. Kochan, Sophie Nozick, Timothy Ward, Tania Afzal, Issay Niki, Sumitra D. Mitra, Ethan VanGosen, Julia Nelson, Aliki Valdes, David Hynes, William Cheng, Joanne Lee, Prarthana Prashanth, Timothy L. Turner, Nathan B. Pincus, Marc H. Scheetz, Kelly E. R. Bachta, Alan R. Hauser
Format: Article
Language:English
Published: American Society for Microbiology 2025-02-01
Series:Microbiology Spectrum
Subjects:
Pseudomonas aeruginosa
Galleria mellonella
virulence
Online Access:https://journals.asm.org/doi/10.1128/spectrum.01666-24
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