Communication between the gut microbiota and peripheral nervous system in health and chronic disease
Trillions of bacteria reside within our gastrointestinal tract, ideally forming a mutually beneficial relationship between us. However, persistent changes in diet and lifestyle in the western diet and lifestyle contribute to a damaging of the gut microbiota-host symbiosis leading to diseases such as...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2022-12-01
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| Series: | Gut Microbes |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/19490976.2022.2068365 |
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| author | Tyler M. Cook Virginie Mansuy-Aubert |
| author_facet | Tyler M. Cook Virginie Mansuy-Aubert |
| author_sort | Tyler M. Cook |
| collection | DOAJ |
| description | Trillions of bacteria reside within our gastrointestinal tract, ideally forming a mutually beneficial relationship between us. However, persistent changes in diet and lifestyle in the western diet and lifestyle contribute to a damaging of the gut microbiota-host symbiosis leading to diseases such as obesity and irritable bowel syndrome. Many symptoms and comorbidities associated with these diseases stem from dysfunctional signaling in peripheral neurons. Our peripheral nervous system (PNS) is comprised of a variety of sensory, autonomic, and enteric neurons which coordinate key homeostatic functions such as gastrointestinal motility, digestion, immunity, feeding behavior, glucose and lipid homeostasis, and more. The composition and signaling of bacteria in our gut dramatically influences how our peripheral neurons regulate these functions, and we are just beginning to uncover the molecular mechanisms mediating this communication. In this review, we cover the general anatomy and function of the PNS, and then we discuss how the molecules secreted or stimulated by gut microbes signal through the PNS to alter host development and physiology. Finally, we discuss how leveraging the power of our gut microbes on peripheral nervous system signaling may offer effective therapies to counteract the rise in chronic diseases crippling the western world. |
| format | Article |
| id | doaj-art-2ff2e388235b4a32886bfd04cee22bea |
| institution | DOAJ |
| issn | 1949-0976 1949-0984 |
| language | English |
| publishDate | 2022-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Gut Microbes |
| spelling | doaj-art-2ff2e388235b4a32886bfd04cee22bea2025-08-20T03:05:24ZengTaylor & Francis GroupGut Microbes1949-09761949-09842022-12-0114110.1080/19490976.2022.2068365Communication between the gut microbiota and peripheral nervous system in health and chronic diseaseTyler M. Cook0Virginie Mansuy-Aubert1Department of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USADepartment of Cell and Molecular Physiology, Loyola University Chicago, Maywood, IL, USATrillions of bacteria reside within our gastrointestinal tract, ideally forming a mutually beneficial relationship between us. However, persistent changes in diet and lifestyle in the western diet and lifestyle contribute to a damaging of the gut microbiota-host symbiosis leading to diseases such as obesity and irritable bowel syndrome. Many symptoms and comorbidities associated with these diseases stem from dysfunctional signaling in peripheral neurons. Our peripheral nervous system (PNS) is comprised of a variety of sensory, autonomic, and enteric neurons which coordinate key homeostatic functions such as gastrointestinal motility, digestion, immunity, feeding behavior, glucose and lipid homeostasis, and more. The composition and signaling of bacteria in our gut dramatically influences how our peripheral neurons regulate these functions, and we are just beginning to uncover the molecular mechanisms mediating this communication. In this review, we cover the general anatomy and function of the PNS, and then we discuss how the molecules secreted or stimulated by gut microbes signal through the PNS to alter host development and physiology. Finally, we discuss how leveraging the power of our gut microbes on peripheral nervous system signaling may offer effective therapies to counteract the rise in chronic diseases crippling the western world.https://www.tandfonline.com/doi/10.1080/19490976.2022.2068365Gut microbiota/ microbiota metabolites/PNS/neuronal sensing/obesity |
| spellingShingle | Tyler M. Cook Virginie Mansuy-Aubert Communication between the gut microbiota and peripheral nervous system in health and chronic disease Gut Microbes Gut microbiota/ microbiota metabolites/PNS/neuronal sensing/obesity |
| title | Communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| title_full | Communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| title_fullStr | Communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| title_full_unstemmed | Communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| title_short | Communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| title_sort | communication between the gut microbiota and peripheral nervous system in health and chronic disease |
| topic | Gut microbiota/ microbiota metabolites/PNS/neuronal sensing/obesity |
| url | https://www.tandfonline.com/doi/10.1080/19490976.2022.2068365 |
| work_keys_str_mv | AT tylermcook communicationbetweenthegutmicrobiotaandperipheralnervoussysteminhealthandchronicdisease AT virginiemansuyaubert communicationbetweenthegutmicrobiotaandperipheralnervoussysteminhealthandchronicdisease |