CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

CCR2+ monocytes infiltrate atrophic lesions in age‐related macular disease and mediate photoreceptor degeneration in experimental subretinal inflammation in Cx3cr1 deficient mice

Abstract Atrophic age‐related macular degeneration (AMD) is associated with the subretinal accumulation of mononuclear phagocytes (MPs). Their role in promoting or inhibiting retinal degeneration is unknown. We here show that atrophic AMD is associated with increased intraocular CCL2 levels and subr...

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Main Authors: Florian Sennlaub, Constance Auvynet, Bertrand Calippe, Sophie Lavalette, Lucie Poupel, Shulong J. Hu, Elisa Dominguez, Serge Camelo, Olivier Levy, Elodie Guyon, Noah Saederup, Israel F. Charo, Nico Van Rooijen, Emeline Nandrot, Jean‐Louis Bourges, Francine Behar‐Cohen, José‐Alain Sahel, Xavier Guillonneau, William Raoul, Christophe Combadiere
Format: Article
Language:English
Published: Springer Nature 2013-10-01
Series:EMBO Molecular Medicine
Subjects:
age‐related macular disease
chemokines
monocyte
neurodegeneration
neuroinflammation
Online Access:https://doi.org/10.1002/emmm.201302692
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