Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic
ABSTRACT Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. Objectives The aim of the study is to evaluate the effect of severity of colic sign...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-05-01
|
| Series: | Journal of Veterinary Internal Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1111/jvim.70073 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849729591297441792 |
|---|---|
| author | Agnieszka Żak‐Bochenek Zuzana Drábková Vaiva Sergedaite Natalia Siwińska Joanna Bajzert Dominika Pasak Anna Chełmońska‐Soyta |
| author_facet | Agnieszka Żak‐Bochenek Zuzana Drábková Vaiva Sergedaite Natalia Siwińska Joanna Bajzert Dominika Pasak Anna Chełmońska‐Soyta |
| author_sort | Agnieszka Żak‐Bochenek |
| collection | DOAJ |
| description | ABSTRACT Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. Objectives The aim of the study is to evaluate the effect of severity of colic signs and treatments on fecal SIgA and fecal lactate in horses. Animals Sixty‐two client owned hospitalised horses with colic and eight healthy horses. Methods Prospective clinical trial. Fecal samples were taken daily for 7 days. SIgA was analyzed using ELISA, and D/L‐lactate measured with a commercial kit. Results At Day 0, SIgA values in the colic medical and colic surgical groups were significantly higher than in the control stable group (U = 126.0, p = 0.099, Cliff's ∆ = 0.58 and U = 248.0, p = 0.005, Cliff's ∆ = 0.72, respectively). We found significant correlation between fecal SIgA and fecal lactate level in D0 (rs = 0.421, p = 0.038). Conclusions This study demonstrates the feasibility of using fecal samples to identify biomarkers of colic in horses. An increase in fecal SIgA in horses with colic might suggest the presence of inflammation within the intestines and disruption of the mucosal barrier. These data highlight changes in gastrointestinal barrier and immune function and the intestinal microbiota's metabolic activity in horses with colic. |
| format | Article |
| id | doaj-art-2ff1a7d22c2343c88c307fecad7a2488 |
| institution | DOAJ |
| issn | 0891-6640 1939-1676 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Veterinary Internal Medicine |
| spelling | doaj-art-2ff1a7d22c2343c88c307fecad7a24882025-08-20T03:09:11ZengWileyJournal of Veterinary Internal Medicine0891-66401939-16762025-05-01393n/an/a10.1111/jvim.70073Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With ColicAgnieszka Żak‐Bochenek0Zuzana Drábková1Vaiva Sergedaite2Natalia Siwińska3Joanna Bajzert4Dominika Pasak5Anna Chełmońska‐Soyta6Department of Immunology, Pathophysiology and Veterinary Preventive Medicine Wroclaw University of Environmental and Life Sciences Wroclaw PolandEquine Clinic, Faculty of Veterinary Medicine University of Veterinary Sciences Brno Brno Czech RepublicEquine Clinic, Faculty of Veterinary Medicine University of Veterinary Sciences Brno Brno Czech RepublicDepartment of Internal Diseases With Clinic of Horses, Dogs and Cats Wroclaw University of Environmental and Life Sciences Wroclaw PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine Wroclaw University of Environmental and Life Sciences Wroclaw PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine Wroclaw University of Environmental and Life Sciences Wroclaw PolandDepartment of Immunology, Pathophysiology and Veterinary Preventive Medicine Wroclaw University of Environmental and Life Sciences Wroclaw PolandABSTRACT Background Colic‐related obstructions can reduced intestinal mucosa function and cause dysbiosis in horses, but it is unclear how defense barrier and secretory immunoglobulin A (SIgA) secretion is disrupted. Objectives The aim of the study is to evaluate the effect of severity of colic signs and treatments on fecal SIgA and fecal lactate in horses. Animals Sixty‐two client owned hospitalised horses with colic and eight healthy horses. Methods Prospective clinical trial. Fecal samples were taken daily for 7 days. SIgA was analyzed using ELISA, and D/L‐lactate measured with a commercial kit. Results At Day 0, SIgA values in the colic medical and colic surgical groups were significantly higher than in the control stable group (U = 126.0, p = 0.099, Cliff's ∆ = 0.58 and U = 248.0, p = 0.005, Cliff's ∆ = 0.72, respectively). We found significant correlation between fecal SIgA and fecal lactate level in D0 (rs = 0.421, p = 0.038). Conclusions This study demonstrates the feasibility of using fecal samples to identify biomarkers of colic in horses. An increase in fecal SIgA in horses with colic might suggest the presence of inflammation within the intestines and disruption of the mucosal barrier. These data highlight changes in gastrointestinal barrier and immune function and the intestinal microbiota's metabolic activity in horses with colic.https://doi.org/10.1111/jvim.70073abdomenhorsesintestinelactates |
| spellingShingle | Agnieszka Żak‐Bochenek Zuzana Drábková Vaiva Sergedaite Natalia Siwińska Joanna Bajzert Dominika Pasak Anna Chełmońska‐Soyta Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic Journal of Veterinary Internal Medicine abdomen horses intestine lactates |
| title | Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic |
| title_full | Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic |
| title_fullStr | Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic |
| title_full_unstemmed | Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic |
| title_short | Fecal Secretory Immunoglobulin A and Lactate Level as a Biomarker of Mucosal Immune Dysfunction in Horses With Colic |
| title_sort | fecal secretory immunoglobulin a and lactate level as a biomarker of mucosal immune dysfunction in horses with colic |
| topic | abdomen horses intestine lactates |
| url | https://doi.org/10.1111/jvim.70073 |
| work_keys_str_mv | AT agnieszkazakbochenek fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT zuzanadrabkova fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT vaivasergedaite fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT nataliasiwinska fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT joannabajzert fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT dominikapasak fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic AT annachełmonskasoyta fecalsecretoryimmunoglobulinaandlactatelevelasabiomarkerofmucosalimmunedysfunctioninhorseswithcolic |