A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis
Renal interstitial fibrosis is a necessary stage in the development of many chronic renal diseases. Signal pathways regulate the transcription of a variety of functional genes and participate in many important physiological and pathological processes. Signal pathways play an important role in the oc...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | zho |
| Published: |
Editorial Department of Journal of Clinical Nephrology
2019-01-01
|
| Series: | Linchuang shenzangbing zazhi |
| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57910485&Fpath=home&index=0 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849728834058846208 |
|---|---|
| author | ZHANG Man LI Jun |
| author_facet | ZHANG Man LI Jun |
| author_sort | ZHANG Man |
| collection | DOAJ |
| description | Renal interstitial fibrosis is a necessary stage in the development of many chronic renal diseases. Signal pathways regulate the transcription of a variety of functional genes and participate in many important physiological and pathological processes. Signal pathways play an important role in the occurrence and development of renal interstitial fibrosis. Both TGF and Notch signaling pathways are involved in the occurrence and development of renal fibrosis. Intervention of TGF and Notch signaling pathways can delay the progression of renal interstitial fibrosis. It is shown that TGF signaling pathway and Notch signaling pathway not only play an independent role, but also interact with each other. Both of them not only regulate the activity of each signal pathway component, but also regulate the common downstream target genes and expression products, so as to regulate the occurrence and development of renal interstitial fibrosis. Therefore, further studies of the relationship between the two pathways may provide a new entry point for the study of anti-renal fibrosis. |
| format | Article |
| id | doaj-art-2ff0c4022cbd411389fbfb7babe0ba6d |
| institution | DOAJ |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2019-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-2ff0c4022cbd411389fbfb7babe0ba6d2025-08-20T03:09:25ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902019-01-011970570957910485A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosisZHANG ManLI JunRenal interstitial fibrosis is a necessary stage in the development of many chronic renal diseases. Signal pathways regulate the transcription of a variety of functional genes and participate in many important physiological and pathological processes. Signal pathways play an important role in the occurrence and development of renal interstitial fibrosis. Both TGF and Notch signaling pathways are involved in the occurrence and development of renal fibrosis. Intervention of TGF and Notch signaling pathways can delay the progression of renal interstitial fibrosis. It is shown that TGF signaling pathway and Notch signaling pathway not only play an independent role, but also interact with each other. Both of them not only regulate the activity of each signal pathway component, but also regulate the common downstream target genes and expression products, so as to regulate the occurrence and development of renal interstitial fibrosis. Therefore, further studies of the relationship between the two pathways may provide a new entry point for the study of anti-renal fibrosis.http://www.lcszb.com/thesisDetails?columnId=57910485&Fpath=home&index=0 |
| spellingShingle | ZHANG Man LI Jun A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis Linchuang shenzangbing zazhi |
| title | A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis |
| title_full | A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis |
| title_fullStr | A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis |
| title_full_unstemmed | A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis |
| title_short | A study on the relationship between Notch and TGF signal pathways in renal interstitial fibrosis |
| title_sort | study on the relationship between notch and tgf signal pathways in renal interstitial fibrosis |
| url | http://www.lcszb.com/thesisDetails?columnId=57910485&Fpath=home&index=0 |
| work_keys_str_mv | AT zhangman astudyontherelationshipbetweennotchandtgfsignalpathwaysinrenalinterstitialfibrosis AT lijun astudyontherelationshipbetweennotchandtgfsignalpathwaysinrenalinterstitialfibrosis AT zhangman studyontherelationshipbetweennotchandtgfsignalpathwaysinrenalinterstitialfibrosis AT lijun studyontherelationshipbetweennotchandtgfsignalpathwaysinrenalinterstitialfibrosis |