PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY
The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved to be effective in the treatment of heart fai...
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| Format: | Article |
| Language: | English |
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Столичная издательская компания
2017-09-01
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| Series: | Рациональная фармакотерапия в кардиологии |
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| Online Access: | https://www.rpcardio.online/jour/article/view/1508 |
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| _version_ | 1849227710216273920 |
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| author | O. M. Drapkina D. U. Akasheva |
| author_facet | O. M. Drapkina D. U. Akasheva |
| author_sort | O. M. Drapkina |
| collection | DOAJ |
| description | The theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved to be effective in the treatment of heart failure with reduced ejection fraction (<40%). Antagonists of mineralocorticoid receptors, along with angiotensin-converting enzyme inhibitors and beta-blockers, are neurohumoral modulators. They are used to treat patients with heart failure with reduced ejection fraction. The prescription of mineralocorticoid receptor antagonists in clinical practice remains insufficient despite their high efficacy. Demonstration of the site of mineralocorticoid receptor antagonists in the complex treatment of a patient with chronic heart failure and diabetes type 2 is the goal of this article. |
| format | Article |
| id | doaj-art-2feb8327e26d423387d2e8d5dad82d5b |
| institution | Kabale University |
| issn | 1819-6446 2225-3653 |
| language | English |
| publishDate | 2017-09-01 |
| publisher | Столичная издательская компания |
| record_format | Article |
| series | Рациональная фармакотерапия в кардиологии |
| spelling | doaj-art-2feb8327e26d423387d2e8d5dad82d5b2025-08-23T10:00:28ZengСтоличная издательская компанияРациональная фармакотерапия в кардиологии1819-64462225-36532017-09-0113448248810.20996/1819-6446-2017-13-4-482-4881366PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPYO. M. Drapkina0D. U. Akasheva1National Medical Research Center for Preventive MedicineNational Medical Research Center for Preventive MedicineThe theory of chronic hyperactivation of neurohormonal systems, in particular, sympathoadrenal and renin-angiotensin-aldosterone, is the basis of modern concepts of the pathogenesis of heart failure. The medicinal blocking of these two systems has proved to be effective in the treatment of heart failure with reduced ejection fraction (<40%). Antagonists of mineralocorticoid receptors, along with angiotensin-converting enzyme inhibitors and beta-blockers, are neurohumoral modulators. They are used to treat patients with heart failure with reduced ejection fraction. The prescription of mineralocorticoid receptor antagonists in clinical practice remains insufficient despite their high efficacy. Demonstration of the site of mineralocorticoid receptor antagonists in the complex treatment of a patient with chronic heart failure and diabetes type 2 is the goal of this article.https://www.rpcardio.online/jour/article/view/1508heart failure with reduced ejection fractionmineralocorticoid receptor antagonistseplerenone |
| spellingShingle | O. M. Drapkina D. U. Akasheva PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY Рациональная фармакотерапия в кардиологии heart failure with reduced ejection fraction mineralocorticoid receptor antagonists eplerenone |
| title | PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY |
| title_full | PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY |
| title_fullStr | PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY |
| title_full_unstemmed | PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY |
| title_short | PATIENT WITH CHRONIC HEART FAILURE. RATIONAL CHOICE OF THERAPY |
| title_sort | patient with chronic heart failure rational choice of therapy |
| topic | heart failure with reduced ejection fraction mineralocorticoid receptor antagonists eplerenone |
| url | https://www.rpcardio.online/jour/article/view/1508 |
| work_keys_str_mv | AT omdrapkina patientwithchronicheartfailurerationalchoiceoftherapy AT duakasheva patientwithchronicheartfailurerationalchoiceoftherapy |