Tuberculosis: New Aspects of an Old Disease
Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Cell Biology |
| Online Access: | http://dx.doi.org/10.1155/2011/403623 |
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| _version_ | 1850217939132743680 |
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| author | Luisa Jordao Otilia V. Vieira |
| author_facet | Luisa Jordao Otilia V. Vieira |
| author_sort | Luisa Jordao |
| collection | DOAJ |
| description | Tuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculosis interference with phagosome maturation, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade. |
| format | Article |
| id | doaj-art-2fe8f89374424a0280bde524cd38f8b8 |
| institution | OA Journals |
| issn | 1687-8876 1687-8884 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Cell Biology |
| spelling | doaj-art-2fe8f89374424a0280bde524cd38f8b82025-08-20T02:07:56ZengWileyInternational Journal of Cell Biology1687-88761687-88842011-01-01201110.1155/2011/403623403623Tuberculosis: New Aspects of an Old DiseaseLuisa Jordao0Otilia V. Vieira1Department of Infectious Diseases, National Institute of Health, 1649-016 Lisbon, PortugalCenter for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, PortugalTuberculosis is an ancient infectious disease that remains a threat for public health around the world. Although the etiological agent as well as tuberculosis pathogenesis is well known, the molecular mechanisms underlying the host defense to the bacilli remain elusive. In this paper we focus on the innate immunity of this disease reviewing well-established and consensual mechanisms like Mycobacterium tuberculosis interference with phagosome maturation, less consensual mechanism like nitric oxide production, and new mechanisms, such as mycobacteria translocation to the cytosol, autophagy, and apoptosis/necrosis proposed mainly during the last decade.http://dx.doi.org/10.1155/2011/403623 |
| spellingShingle | Luisa Jordao Otilia V. Vieira Tuberculosis: New Aspects of an Old Disease International Journal of Cell Biology |
| title | Tuberculosis: New Aspects of an Old Disease |
| title_full | Tuberculosis: New Aspects of an Old Disease |
| title_fullStr | Tuberculosis: New Aspects of an Old Disease |
| title_full_unstemmed | Tuberculosis: New Aspects of an Old Disease |
| title_short | Tuberculosis: New Aspects of an Old Disease |
| title_sort | tuberculosis new aspects of an old disease |
| url | http://dx.doi.org/10.1155/2011/403623 |
| work_keys_str_mv | AT luisajordao tuberculosisnewaspectsofanolddisease AT otiliavvieira tuberculosisnewaspectsofanolddisease |