Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients
Objective To observe the effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis （MHD） patients. Methods From June 2023 to August 2023， patients with end-stage renal disease （ESRD） on MHD were randomized into two groups of nutritional-su...
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Editorial Department of Journal of Clinical Nephrology
2024-10-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.10.005 |
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| author | Qing Yang Ting-ting Feng Huan Li Ling-li Du |
| author_facet | Qing Yang Ting-ting Feng Huan Li Ling-li Du |
| author_sort | Qing Yang |
| collection | DOAJ |
| description | Objective To observe the effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis （MHD） patients. Methods From June 2023 to August 2023， patients with end-stage renal disease （ESRD） on MHD were randomized into two groups of nutritional-support and conventional-treatment （n = 35 each）. Conventional-treatment group received routine treatment while nutritional-support group had dietary and nutritional intervention on the basis of routine treatment in control group. The incidence of malnutrition， nutritional parameters， inflammatory factors， calcium and phosphorus metabolism parameters and complications were compared between two groups. Results After 3/6-month intervention， the incidence of malnutritionwas lower in nutritional-support group than that in conventional-treatment group （31.43% vs 57.14%，11.43% vs 34.29%，P＜0.05）； after 3-month intervention， the levels of hemoglobin （Hb）[（126.78 ± 11.22）g/L vs （115.39 ± 10.04）g/L]，prealbumin （PA）[（316.44 ± 25.26）g/L vs （287.54 ± 26.10）g/L] and albumin （Alb）[（46.08 ± 8.15）g/L vs （38.73 ± 8.11）g/L] increased in both groups and nutritional-support group was higher than conventional-treatment group（P＜0.05）；after 3-month intervention， serum levels of C-reactive protein （CRP）[（2.16 ± 0.45）mg/L vs （2.61 ± 0.51）mg/L]， interleukin-6 （IL-6）[（10.83 ± 2.61）ng/L vs （13.43 ± 2.42）ng/L] and tumor necrosis factor-α （TNF-α）[（89.52 ± 9.13）ng/L vs （101.64 ± 9.44）ng/L] decreased in both groups and the nutritional-support group was lower than conventional-treatment group （P＜0.05）； after 3-month intervention， serum levels of calcium （S-Ca）[（2.06 ± 0.20）mmol/L vs （2.25 ± 0.19）mmol/L]， phosphorus （S-P）[（2.20 ± 0.23）mmol/L vs （2.42 ± 0.26）mmol/L]，intact parathyroid hormone （iPTH）[（180.38 ± 44.82）mmol/L vs （216.54 ± 48.44）mmol/L] and Ca×P [（4.53 ± 0.49）mmol/L vs （5.45 ± 0.51）mmol/L] decreased in both groups and nutritional-support group was lower than conventional-treatment group （P＜0.05）； overall incidence of complications was lower in nutritional-support group than that in conventional-treatment group（χ2 = 4.629，P = 0.031）. Conclusion Nutritional support may alleviate the inflammatory response， improve their nutritional status and disrupt calcium and phosphorus metabolism in MHD patients. |
| format | Article |
| id | doaj-art-2fe436970fe8423f81e1ccd654c99213 |
| institution | OA Journals |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
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| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-2fe436970fe8423f81e1ccd654c992132025-08-20T01:47:54ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902024-10-01241082783310.3969/j.issn.1671-2390.2024.10.00520230467Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patientsQing Yang0Ting-ting Feng1Huan Li2Ling-li Du3Department of Nephrology & Blood Purification Center， Jingmen People's Hospital， Jingmen 448000, ChinaDepartment of Nephrology & Blood Purification Center， Jingmen People's Hospital， Jingmen 448000, ChinaDepartment of Nephrology & Blood Purification Center， Jingmen People's Hospital， Jingmen 448000, ChinaDepartment of Nephrology & Blood Purification Center， Jingmen People's Hospital， Jingmen 448000, ChinaObjective To observe the effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis （MHD） patients. Methods From June 2023 to August 2023， patients with end-stage renal disease （ESRD） on MHD were randomized into two groups of nutritional-support and conventional-treatment （n = 35 each）. Conventional-treatment group received routine treatment while nutritional-support group had dietary and nutritional intervention on the basis of routine treatment in control group. The incidence of malnutrition， nutritional parameters， inflammatory factors， calcium and phosphorus metabolism parameters and complications were compared between two groups. Results After 3/6-month intervention， the incidence of malnutritionwas lower in nutritional-support group than that in conventional-treatment group （31.43% vs 57.14%，11.43% vs 34.29%，P＜0.05）； after 3-month intervention， the levels of hemoglobin （Hb）[（126.78 ± 11.22）g/L vs （115.39 ± 10.04）g/L]，prealbumin （PA）[（316.44 ± 25.26）g/L vs （287.54 ± 26.10）g/L] and albumin （Alb）[（46.08 ± 8.15）g/L vs （38.73 ± 8.11）g/L] increased in both groups and nutritional-support group was higher than conventional-treatment group（P＜0.05）；after 3-month intervention， serum levels of C-reactive protein （CRP）[（2.16 ± 0.45）mg/L vs （2.61 ± 0.51）mg/L]， interleukin-6 （IL-6）[（10.83 ± 2.61）ng/L vs （13.43 ± 2.42）ng/L] and tumor necrosis factor-α （TNF-α）[（89.52 ± 9.13）ng/L vs （101.64 ± 9.44）ng/L] decreased in both groups and the nutritional-support group was lower than conventional-treatment group （P＜0.05）； after 3-month intervention， serum levels of calcium （S-Ca）[（2.06 ± 0.20）mmol/L vs （2.25 ± 0.19）mmol/L]， phosphorus （S-P）[（2.20 ± 0.23）mmol/L vs （2.42 ± 0.26）mmol/L]，intact parathyroid hormone （iPTH）[（180.38 ± 44.82）mmol/L vs （216.54 ± 48.44）mmol/L] and Ca×P [（4.53 ± 0.49）mmol/L vs （5.45 ± 0.51）mmol/L] decreased in both groups and nutritional-support group was lower than conventional-treatment group （P＜0.05）； overall incidence of complications was lower in nutritional-support group than that in conventional-treatment group（χ2 = 4.629，P = 0.031）. Conclusion Nutritional support may alleviate the inflammatory response， improve their nutritional status and disrupt calcium and phosphorus metabolism in MHD patients.http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.10.005maintenance hemodialysisnutritional supportnutritional statusinflammatory factorcalcium and phosphorus metabolism |
| spellingShingle | Qing Yang Ting-ting Feng Huan Li Ling-li Du Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients Linchuang shenzangbing zazhi maintenance hemodialysis nutritional support nutritional status inflammatory factor calcium and phosphorus metabolism |
| title | Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| title_full | Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| title_fullStr | Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| title_full_unstemmed | Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| title_short | Effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| title_sort | effects of nutritional support on nutritional status and calcium and phosphorus metabolism in maintenance hemodialysis patients |
| topic | maintenance hemodialysis nutritional support nutritional status inflammatory factor calcium and phosphorus metabolism |
| url | http://www.lcszb.com/cn/article/doi/10.3969/j.issn.1671-2390.2024.10.005 |
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