Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis
Sepsis is defined as a life-threatening disease involving multiple organ dysfunction caused by dysregulated host responses to infection. To date, sepsis remains a dominant cause of death among critically ill patients. Pyroptosis is a unique form of programmed cell death mediated by the gasdermin fam...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2021/9925059 |
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| author | Ran Guo Hao Wang Na Cui |
| author_facet | Ran Guo Hao Wang Na Cui |
| author_sort | Ran Guo |
| collection | DOAJ |
| description | Sepsis is defined as a life-threatening disease involving multiple organ dysfunction caused by dysregulated host responses to infection. To date, sepsis remains a dominant cause of death among critically ill patients. Pyroptosis is a unique form of programmed cell death mediated by the gasdermin family of proteins and causes lytic cell death and release of proinflammatory cytokines. Although there might be some positive aspects to pyroptosis, it is regarded as harmful during sepsis and needs to be restricted. Autophagy was originally characterized as a homeostasis-maintaining mechanism in living cells. In the past decade, its function in negatively modulating pyroptosis and inflammation during sepsis has attracted increased attention. Here, we present a comprehensive review of the regulatory effect of autophagy on pyroptosis during sepsis, including the latest advances in our understanding of the mechanism and signaling pathways involved, as well as the potential therapeutic application in sepsis. |
| format | Article |
| id | doaj-art-2fe2a467bd964eb9a30bfacfe489b403 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-2fe2a467bd964eb9a30bfacfe489b4032025-08-20T03:20:22ZengWileyMediators of Inflammation0962-93511466-18612021-01-01202110.1155/2021/99250599925059Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in SepsisRan Guo0Hao Wang1Na Cui2Department of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaDepartment of Critical Care Medicine, State Key Laboratory of Complex Severe and Rare Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100730, ChinaSepsis is defined as a life-threatening disease involving multiple organ dysfunction caused by dysregulated host responses to infection. To date, sepsis remains a dominant cause of death among critically ill patients. Pyroptosis is a unique form of programmed cell death mediated by the gasdermin family of proteins and causes lytic cell death and release of proinflammatory cytokines. Although there might be some positive aspects to pyroptosis, it is regarded as harmful during sepsis and needs to be restricted. Autophagy was originally characterized as a homeostasis-maintaining mechanism in living cells. In the past decade, its function in negatively modulating pyroptosis and inflammation during sepsis has attracted increased attention. Here, we present a comprehensive review of the regulatory effect of autophagy on pyroptosis during sepsis, including the latest advances in our understanding of the mechanism and signaling pathways involved, as well as the potential therapeutic application in sepsis.http://dx.doi.org/10.1155/2021/9925059 |
| spellingShingle | Ran Guo Hao Wang Na Cui Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis Mediators of Inflammation |
| title | Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis |
| title_full | Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis |
| title_fullStr | Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis |
| title_full_unstemmed | Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis |
| title_short | Autophagy Regulation on Pyroptosis: Mechanism and Medical Implication in Sepsis |
| title_sort | autophagy regulation on pyroptosis mechanism and medical implication in sepsis |
| url | http://dx.doi.org/10.1155/2021/9925059 |
| work_keys_str_mv | AT ranguo autophagyregulationonpyroptosismechanismandmedicalimplicationinsepsis AT haowang autophagyregulationonpyroptosismechanismandmedicalimplicationinsepsis AT nacui autophagyregulationonpyroptosismechanismandmedicalimplicationinsepsis |