Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19
Background. Patients with moderate or severe COVID-19 infection suffer from varying levels of fatigue; however, there is a lack of understanding regarding the effect of inflammation on fatigue; and whether these relationships differ according to the severity of the infection. Aim. To assess the rela...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2023/7057458 |
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| author | Besher A. Gharaibeh Jehad Rababah Obieda Haneyah |
| author_facet | Besher A. Gharaibeh Jehad Rababah Obieda Haneyah |
| author_sort | Besher A. Gharaibeh |
| collection | DOAJ |
| description | Background. Patients with moderate or severe COVID-19 infection suffer from varying levels of fatigue; however, there is a lack of understanding regarding the effect of inflammation on fatigue; and whether these relationships differ according to the severity of the infection. Aim. To assess the relationships between selected inflammatory biomarkers and fatigue levels among hospitalized Jordanian patients with moderate or severe COVID-19 infection. Methods. A quantitative cross-sectional design was used. A total of 352 participants were recruited for the study. Data regarding fatigue type and level were collected using the Chalder fatigue scale. Laboratory test results regarding several selected inflammatory biomarkers (e.g., ESR, CRP, IL-6, D-dimer, and others) were collected from patient records. The severity of the COVID-19 infection was determined using the criteria of the Ministry of Health in Jordan based on the results of O2% (oxygen saturation). Results. The mean scores of the total fatigue level significantly differed between the two levels of the severity of COVID-19 infection (moderate and severe levels) (t = −3.0, p<0.05). Similar findings were observed with physiological fatigue (t = −3.50, p<0.05), and no significant difference was observed in psychological fatigue. Out of the selected inflammatory markers, only neutrophil and lymphocyte count had a significant influence on total fatigue level. Conclusion. The level and type of fatigue was affected by the severity of the disease. However, the disease process itself represented by the levels of the inflammatory markers showed little influence on fatigue. The implications such as continuous screening of fatigue, and monitoring of the levels of the inflammatory markers are important to assist in diagnosing and managing COVID-19 patients. Furthermore, the relationship between the inflammatory process and fatigue is complex and requires further exploration. |
| format | Article |
| id | doaj-art-2fdcd076c76640ffa78e40e1296a0c5d |
| institution | DOAJ |
| issn | 2042-0099 |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-2fdcd076c76640ffa78e40e1296a0c5d2025-08-20T03:18:34ZengWileyInternational Journal of Inflammation2042-00992023-01-01202310.1155/2023/7057458Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19Besher A. Gharaibeh0Jehad Rababah1Obieda Haneyah2Jordan University of Science and TechnologyJordan University of Science and TechnologyJordan University of Science and TechnologyBackground. Patients with moderate or severe COVID-19 infection suffer from varying levels of fatigue; however, there is a lack of understanding regarding the effect of inflammation on fatigue; and whether these relationships differ according to the severity of the infection. Aim. To assess the relationships between selected inflammatory biomarkers and fatigue levels among hospitalized Jordanian patients with moderate or severe COVID-19 infection. Methods. A quantitative cross-sectional design was used. A total of 352 participants were recruited for the study. Data regarding fatigue type and level were collected using the Chalder fatigue scale. Laboratory test results regarding several selected inflammatory biomarkers (e.g., ESR, CRP, IL-6, D-dimer, and others) were collected from patient records. The severity of the COVID-19 infection was determined using the criteria of the Ministry of Health in Jordan based on the results of O2% (oxygen saturation). Results. The mean scores of the total fatigue level significantly differed between the two levels of the severity of COVID-19 infection (moderate and severe levels) (t = −3.0, p<0.05). Similar findings were observed with physiological fatigue (t = −3.50, p<0.05), and no significant difference was observed in psychological fatigue. Out of the selected inflammatory markers, only neutrophil and lymphocyte count had a significant influence on total fatigue level. Conclusion. The level and type of fatigue was affected by the severity of the disease. However, the disease process itself represented by the levels of the inflammatory markers showed little influence on fatigue. The implications such as continuous screening of fatigue, and monitoring of the levels of the inflammatory markers are important to assist in diagnosing and managing COVID-19 patients. Furthermore, the relationship between the inflammatory process and fatigue is complex and requires further exploration.http://dx.doi.org/10.1155/2023/7057458 |
| spellingShingle | Besher A. Gharaibeh Jehad Rababah Obieda Haneyah Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 International Journal of Inflammation |
| title | Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 |
| title_full | Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 |
| title_fullStr | Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 |
| title_full_unstemmed | Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 |
| title_short | Relationships between Inflammatory Biomarkers and Fatigue among Patients with Moderate and Severe COVID-19 |
| title_sort | relationships between inflammatory biomarkers and fatigue among patients with moderate and severe covid 19 |
| url | http://dx.doi.org/10.1155/2023/7057458 |
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