Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases
Abstract Purpose The aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment. Metho...
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2025-04-01
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| Series: | BMC Gastroenterology |
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| Online Access: | https://doi.org/10.1186/s12876-025-03835-w |
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| author | Anna Lindhoff Larsson Peter Holka Bengt Isaksson Oskar Hemmingsson Per Sandström Bergthór Björnsson |
| author_facet | Anna Lindhoff Larsson Peter Holka Bengt Isaksson Oskar Hemmingsson Per Sandström Bergthór Björnsson |
| author_sort | Anna Lindhoff Larsson |
| collection | DOAJ |
| description | Abstract Purpose The aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment. Methods The Swedish versions of the EORTC QLQ-C30 and EORTC QLQ-LMC21 were administered to 250 patients with liver metastases from CRC in four Swedish hospitals before and 3 months after surgical treatment. Psychometric validation of the questionnaire´s structure, reliability, and convergent and divergent validity was performed. Results Data from 242 (97%) patients were suitable for analysis. The QLQ-LMC21 was found to be sensitive to changes over time. Cronbach´s alpha coefficient indicated good internal consistency, ranging from 0.84 to 0.89. Test–retest reliability was evaluated in 120 patients (49%), and the intraclass correlation coefficient (ICC) indicated good reproducibility, ranging from 0.67 to 0.93. Convergent and discriminant validity were demonstrated adequately in the multitrait scaling analysis. There were weak correlations between the QLQ-C30 and QLQ-LMC21, which confirms that the health problems addressed by the QLQ-LMC21 are different from those addressed by the QLQ-C30. Conclusions The Swedish version of the EORTC QLQ-LMC21 proved to be a valid and reliable questionnaire to use in conjunction with the EORTC QLQ-C30. |
| format | Article |
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| institution | DOAJ |
| issn | 1471-230X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
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| series | BMC Gastroenterology |
| spelling | doaj-art-2fdcb02f245e450eb032305f33f77a932025-08-20T03:14:06ZengBMCBMC Gastroenterology1471-230X2025-04-012511910.1186/s12876-025-03835-wTranslation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastasesAnna Lindhoff Larsson0Peter Holka1Bengt Isaksson2Oskar Hemmingsson3Per Sandström4Bergthór Björnsson5Department of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping UniversityDepartment of Surgery, Clinical Sciences Lund, Lund University and Skåne University HospitalDepartment of Surgical Sciences, Sweden Department of Surgery, Uppsala University, Akademiska HospitalDepartment of Surgical and Perioperative Sciences, Surgery, Umeå UniversityDepartment of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping UniversityDepartment of Surgery in Linköping, and Department of Biomedical and Clinical Sciences, Linköping UniversityAbstract Purpose The aim of this study was to translate the health-related quality-of-life questionnaire EORTC QLQ-LMC21 into Swedish and to test its clinical and psychometric reliability and validity in patients with liver metastases from colorectal cancer (CRC) undergoing surgical treatment. Methods The Swedish versions of the EORTC QLQ-C30 and EORTC QLQ-LMC21 were administered to 250 patients with liver metastases from CRC in four Swedish hospitals before and 3 months after surgical treatment. Psychometric validation of the questionnaire´s structure, reliability, and convergent and divergent validity was performed. Results Data from 242 (97%) patients were suitable for analysis. The QLQ-LMC21 was found to be sensitive to changes over time. Cronbach´s alpha coefficient indicated good internal consistency, ranging from 0.84 to 0.89. Test–retest reliability was evaluated in 120 patients (49%), and the intraclass correlation coefficient (ICC) indicated good reproducibility, ranging from 0.67 to 0.93. Convergent and discriminant validity were demonstrated adequately in the multitrait scaling analysis. There were weak correlations between the QLQ-C30 and QLQ-LMC21, which confirms that the health problems addressed by the QLQ-LMC21 are different from those addressed by the QLQ-C30. Conclusions The Swedish version of the EORTC QLQ-LMC21 proved to be a valid and reliable questionnaire to use in conjunction with the EORTC QLQ-C30.https://doi.org/10.1186/s12876-025-03835-wQuality of life (QoL)Colorectal cancerEORTC QLQ-LMC21Psychometric validation |
| spellingShingle | Anna Lindhoff Larsson Peter Holka Bengt Isaksson Oskar Hemmingsson Per Sandström Bergthór Björnsson Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases BMC Gastroenterology Quality of life (QoL) Colorectal cancer EORTC QLQ-LMC21 Psychometric validation |
| title | Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases |
| title_full | Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases |
| title_fullStr | Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases |
| title_full_unstemmed | Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases |
| title_short | Translation and validation of the Swedish version of the EORTC LMC-21, the disease-specific questionnaire for assessing health-related quality of life in patients with colorectal liver metastases |
| title_sort | translation and validation of the swedish version of the eortc lmc 21 the disease specific questionnaire for assessing health related quality of life in patients with colorectal liver metastases |
| topic | Quality of life (QoL) Colorectal cancer EORTC QLQ-LMC21 Psychometric validation |
| url | https://doi.org/10.1186/s12876-025-03835-w |
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