The gut microbiome and osteoarthritis
Osteoarthritis (OA) is one of the most common degenerative diseases, and the number of patients has been constantly increasing. Non-steroidal anti-inflammatory drugs, glucocorticosteroids, opioids, etc., and surgical procedures, e.g. arthroplasty, are among the most common methods of treatment. Ther...
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Termedia Publishing House
2025-02-01
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| Series: | Rheumatology |
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| Online Access: | https://reu.termedia.pl/The-gut-microbiome-and-osteoarthritis,197061,0,2.html |
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| author | Wiktoria Maria Krupka Gabriela Motyl Joanna Dmowska-Chalaba |
| author_facet | Wiktoria Maria Krupka Gabriela Motyl Joanna Dmowska-Chalaba |
| author_sort | Wiktoria Maria Krupka |
| collection | DOAJ |
| description | Osteoarthritis (OA) is one of the most common degenerative diseases, and the number of patients has been constantly increasing. Non-steroidal anti-inflammatory drugs, glucocorticosteroids, opioids, etc., and surgical procedures, e.g. arthroplasty, are among the most common methods of treatment. There are reasons to believe that the gut microbiome (GMB) may influence inflammatory processes occurring in the pathomechanism of OA. The inflammatory processes occurring in the intestines may lead to disruption of tight junctions and increased concentrations of pro-inflammatory cytokines, resulting in increased permeability of intestines, causing low-grade inflammation, including in the joints. Methods of altering the GMB composition to reduce the inflammatory and joint degenerative processes are known only to some extent, and long-term research is required.
Osteoarthritis, a particularly well-known and very widespread disease due to the aging population, is characterized by moderate and local inflammation. It occurs due to the effects of biomechanical cartilage wear with damage of joint structures, primarily through degenerative processes. OA represents a therapeutic challenge, and any element that can influence its inhibition is highly sought after. Therefore, these methods seem to offer a promising additional approach to treatment. |
| format | Article |
| id | doaj-art-2fdcaae3f8224eb4ae1bd6ef0262f7ac |
| institution | DOAJ |
| issn | 0034-6233 2084-9834 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Rheumatology |
| spelling | doaj-art-2fdcaae3f8224eb4ae1bd6ef0262f7ac2025-08-20T02:58:33ZengTermedia Publishing HouseRheumatology0034-62332084-98342025-02-01631546010.5114/reum/197061197061The gut microbiome and osteoarthritisWiktoria Maria Krupka0https://orcid.org/0009-0003-2369-2396Gabriela Motyl1https://orcid.org/0009-0007-9311-6748Joanna Dmowska-Chalaba2https://orcid.org/0000-0002-3884-6883Medical University of Warsaw, PolandMedical University of Warsaw, PolandEarly Arthritis Clinic, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, PolandOsteoarthritis (OA) is one of the most common degenerative diseases, and the number of patients has been constantly increasing. Non-steroidal anti-inflammatory drugs, glucocorticosteroids, opioids, etc., and surgical procedures, e.g. arthroplasty, are among the most common methods of treatment. There are reasons to believe that the gut microbiome (GMB) may influence inflammatory processes occurring in the pathomechanism of OA. The inflammatory processes occurring in the intestines may lead to disruption of tight junctions and increased concentrations of pro-inflammatory cytokines, resulting in increased permeability of intestines, causing low-grade inflammation, including in the joints. Methods of altering the GMB composition to reduce the inflammatory and joint degenerative processes are known only to some extent, and long-term research is required. Osteoarthritis, a particularly well-known and very widespread disease due to the aging population, is characterized by moderate and local inflammation. It occurs due to the effects of biomechanical cartilage wear with damage of joint structures, primarily through degenerative processes. OA represents a therapeutic challenge, and any element that can influence its inhibition is highly sought after. Therefore, these methods seem to offer a promising additional approach to treatment.https://reu.termedia.pl/The-gut-microbiome-and-osteoarthritis,197061,0,2.htmlosteoarthritisinflammationarthritisgut microbiome |
| spellingShingle | Wiktoria Maria Krupka Gabriela Motyl Joanna Dmowska-Chalaba The gut microbiome and osteoarthritis Rheumatology osteoarthritis inflammation arthritis gut microbiome |
| title | The gut microbiome and osteoarthritis |
| title_full | The gut microbiome and osteoarthritis |
| title_fullStr | The gut microbiome and osteoarthritis |
| title_full_unstemmed | The gut microbiome and osteoarthritis |
| title_short | The gut microbiome and osteoarthritis |
| title_sort | gut microbiome and osteoarthritis |
| topic | osteoarthritis inflammation arthritis gut microbiome |
| url | https://reu.termedia.pl/The-gut-microbiome-and-osteoarthritis,197061,0,2.html |
| work_keys_str_mv | AT wiktoriamariakrupka thegutmicrobiomeandosteoarthritis AT gabrielamotyl thegutmicrobiomeandosteoarthritis AT joannadmowskachalaba thegutmicrobiomeandosteoarthritis AT wiktoriamariakrupka gutmicrobiomeandosteoarthritis AT gabrielamotyl gutmicrobiomeandosteoarthritis AT joannadmowskachalaba gutmicrobiomeandosteoarthritis |