High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.

High-throughput screening of the ReFRAME, Pandemic Box, and COVID Box drug repurposing libraries against SARS-CoV-2 nsp15 endoribonuclease to identify small-molecule inhibitors of viral activity.

SARS-CoV-2 has caused a global pandemic, and has taken over 1.7 million lives as of mid-December, 2020. Although great progress has been made in the development of effective countermeasures, with several pharmaceutical companies approved or poised to deliver vaccines to market, there is still an unm...

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Main Authors: Ryan Choi, Mowei Zhou, Roger Shek, Jesse W Wilson, Logan Tillery, Justin K Craig, Indraneel A Salukhe, Sarah E Hickson, Neeraj Kumar, Rhema M James, Garry W Buchko, Ruilian Wu, Sydney Huff, Tu-Trinh Nguyen, Brett L Hurst, Sara Cherry, Lynn K Barrett, Jennifer L Hyde, Wesley C Van Voorhis
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0250019&type=printable
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