Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes
New Schiff compounds based on benzidine (Seven compounds, A–G, 80–90 %) are prepared from the condensation of seven aromatic aldehydes. These agents were characterized by 13C, 1H NMR, HRMS, FTIR, and M.P. The potency of these compounds was examined against Escherichia coli (E. coli). Compounds A–G s...
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| Language: | English |
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Elsevier
2025-01-01
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| Series: | Results in Chemistry |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2211715625000256 |
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| author | Mohammed Adnan Abid Mustafa A-Jabbar Al-Jumaili Ali Adnan Abed |
| author_facet | Mohammed Adnan Abid Mustafa A-Jabbar Al-Jumaili Ali Adnan Abed |
| author_sort | Mohammed Adnan Abid |
| collection | DOAJ |
| description | New Schiff compounds based on benzidine (Seven compounds, A–G, 80–90 %) are prepared from the condensation of seven aromatic aldehydes. These agents were characterized by 13C, 1H NMR, HRMS, FTIR, and M.P. The potency of these compounds was examined against Escherichia coli (E. coli). Compounds A–G show the optimal results by the bacterial growth inhibition, where MIC values were 8, 32, 16, 128, 2, 8 and 8 μg/mL respectively. The gene expression using qRT-PCR has been determined. The two genes of E. coli (oxyR1 and perR) expressed downregulated when treated with all compounds, specifically A and E. These genes are control for example biosynthesis of cell walls. Targeting these two genes plays a role to inhibiting the bacterial growth of E. coli. |
| format | Article |
| id | doaj-art-2fd9efe8d6bb4ab0842cc529114f6b53 |
| institution | Kabale University |
| issn | 2211-7156 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Results in Chemistry |
| spelling | doaj-art-2fd9efe8d6bb4ab0842cc529114f6b532025-01-29T05:01:06ZengElsevierResults in Chemistry2211-71562025-01-0113102042Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genesMohammed Adnan Abid0Mustafa A-Jabbar Al-Jumaili1Ali Adnan Abed2Department of Chemistry, College of Science, University of Anbar, Anbarshire, IraqCollege of Medicine, University of Fallujah, Iraq; Corresponding author.Specialist Supervising Department, Anbar Educational Directorate, Anbarshire, IraqNew Schiff compounds based on benzidine (Seven compounds, A–G, 80–90 %) are prepared from the condensation of seven aromatic aldehydes. These agents were characterized by 13C, 1H NMR, HRMS, FTIR, and M.P. The potency of these compounds was examined against Escherichia coli (E. coli). Compounds A–G show the optimal results by the bacterial growth inhibition, where MIC values were 8, 32, 16, 128, 2, 8 and 8 μg/mL respectively. The gene expression using qRT-PCR has been determined. The two genes of E. coli (oxyR1 and perR) expressed downregulated when treated with all compounds, specifically A and E. These genes are control for example biosynthesis of cell walls. Targeting these two genes plays a role to inhibiting the bacterial growth of E. coli.http://www.sciencedirect.com/science/article/pii/S2211715625000256Schiff baseE. coliBiofilmGene expression |
| spellingShingle | Mohammed Adnan Abid Mustafa A-Jabbar Al-Jumaili Ali Adnan Abed Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes Results in Chemistry Schiff base E. coli Biofilm Gene expression |
| title | Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes |
| title_full | Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes |
| title_fullStr | Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes |
| title_full_unstemmed | Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes |
| title_short | Synthesis, characterization and gene expression of novel bis-Schiff base compounds and study their anti-bacterial activity using different genes |
| title_sort | synthesis characterization and gene expression of novel bis schiff base compounds and study their anti bacterial activity using different genes |
| topic | Schiff base E. coli Biofilm Gene expression |
| url | http://www.sciencedirect.com/science/article/pii/S2211715625000256 |
| work_keys_str_mv | AT mohammedadnanabid synthesischaracterizationandgeneexpressionofnovelbisschiffbasecompoundsandstudytheirantibacterialactivityusingdifferentgenes AT mustafaajabbaraljumaili synthesischaracterizationandgeneexpressionofnovelbisschiffbasecompoundsandstudytheirantibacterialactivityusingdifferentgenes AT aliadnanabed synthesischaracterizationandgeneexpressionofnovelbisschiffbasecompoundsandstudytheirantibacterialactivityusingdifferentgenes |