The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes

The Role of HMGB1 in the Pathogenesis of Type 2 Diabetes

Significance. With an alarming increase in recent years, diabetes mellitus has become a global challenge. Despite advances in treatment of diabetes mellitus, currently, medications available are unable to control the progression of diabetes and its complications. Growing evidence suggests that infla...

Full description

Saved in:

Bibliographic Details
Main Authors:	Yanan Wang, Jixin Zhong, Xiangzhi Zhang, Ziwei Liu, Yuan Yang, Quan Gong, Boxu Ren
Format:	Article
Language:	English
Published:	Wiley 2016-01-01
Series:	Journal of Diabetes Research
Online Access:	http://dx.doi.org/10.1155/2016/2543268
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Role of T Lymphocytes in Type 2 Diabetes and Diabetes-Associated Inflammation
by: Chang Xia, et al.
Published: (2017-01-01)

Inflammatory Regulation in Diabetes and Metabolic Dysfunction
by: Jixin Zhong, et al.
Published: (2017-01-01)

Matrine Ameliorates Colorectal Cancer in Rats via Inhibition of HMGB1 Signaling and Downregulation of IL-6, TNF-α, and HMGB1
by: Huizhen Fan, et al.
Published: (2018-01-01)

HMGB1 Localization during Experimental Periodontitis
by: Andressa Vilas Boas Nogueira, et al.
Published: (2014-01-01)

Plasma C1q/TNF-Related Protein-3 (CTRP-3) and High-Mobility Group Box-1 (HMGB-1) Concentrations in Subjects with Prediabetes and Type 2 Diabetes
by: Huili Wei, et al.
Published: (2016-01-01)

The Role of Autophagy in the Pathogenesis of Diabetic Nephropathy
by: Kosuke Yamahara, et al.
Published: (2013-01-01)

The role of Box A of HMGB1 in producing γH2AX associated DNA breaks in lung cancer
by: Sirapat Settayanon, et al.
Published: (2025-01-01)

The Role of MIF in Type 1 and Type 2 Diabetes Mellitus
by: Yuriko I. Sánchez-Zamora, et al.
Published: (2014-01-01)

Relationship Between Serum HMGB1 and RAGE Levels and Restenosis in Type 2 Diabetes Mellitus Patients Complicated With Lower Extremity Vascular Disease: A Retrospective Study
by: Jia T, et al.
Published: (2025-02-01)

Editorial: Community series in advances in pathogenesis and therapies of gout, volume II
by: Lihua Duan, et al.
Published: (2025-02-01)

Association between HMGB1 and COPD: A Systematic Review
by: Sebastiano Gangemi, et al.
Published: (2015-01-01)

Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes
by: Lin Ding, et al.
Published: (2014-01-01)

A Possible Role of HMGB1 in DNA Demethylation in CD4+ T Cells from Patients with Systemic Lupus Erythematosus
by: Yaping Li, et al.
Published: (2013-01-01)

Assessing the inflammation in pediatric MOGAD: Significance of CSF HMGB1 and related biomarkers
by: Xin Wang, et al.
Published: (2025-02-01)

HMGB1 Promotes Systemic Lupus Erythematosus by Enhancing Macrophage Inflammatory Response
by: Mudan Lu, et al.
Published: (2015-01-01)

Attenuation of Myocardial Injury by HMGB1 Blockade during Ischemia/Reperfusion Is Toll-Like Receptor 2-Dependent
by: Jan Mersmann, et al.
Published: (2013-01-01)

The role of 1-Deoxysphingolipids and Polyamines in the pathogenesis of placental syndrome
by: Filiz Yarsilikal Guleroglu, et al.
Published: (2025-01-01)

Potential Role of Gene Regulator NFAT5 in the Pathogenesis of Diabetes Mellitus
by: Lusha Cen, et al.
Published: (2020-01-01)

Research progress on the role of extracellular vesicles in the pathogenesis of diabetic kidney disease
by: Jiangyuan Jin, et al.
Published: (2024-12-01)

Involvement of HMGB1 in Resistance to Tumor Vessel-Targeted, Monoclonal Antibody-Based Immunotherapy
by: Vito Pistoia, et al.
Published: (2016-01-01)

Anti-HMGB1 Monoclonal Antibody Ameliorates Immunosuppression after Peripheral Tissue Trauma: Attenuated T-Lymphocyte Response and Increased Splenic CD11b+Gr-1+ Myeloid-Derived Suppressor Cells Require HMGB1
by: Xiangcai Ruan, et al.
Published: (2015-01-01)

Platelet-derived HMGB1 induces NETosis, exacerbating brain damage in the photothrombotic stroke model
by: Sang-A. Oh, et al.
Published: (2025-02-01)

HMGB1 Box A gene therapy to alleviate bleomycin-induced pulmonary fibrosis in rats
by: Rathasapa Patarat, et al.
Published: (2025-01-01)

To Explore the Pathogenesis of Vascular Lesion of Type 2 Diabetes Mellitus Based on the PI3K/Akt Signaling Pathway
by: Jia-Rong Gao, et al.
Published: (2019-01-01)

Integrated Approach for Biomarker Discovery and Mechanistic Insights into the Co-Pathogenesis of Type 2 Diabetes Mellitus and Non-Hodgkin Lymphoma
by: Zhu Y, et al.
Published: (2025-01-01)

The Role of Inflammation in the Pathogenesis of Osteoarthritis
by: Yoke Yue Chow, et al.
Published: (2020-01-01)

The Role of Inflammation in the Pathogenesis of Preeclampsia
by: Michał Michalczyk, et al.
Published: (2020-01-01)

Role of Apoptosis in HIV Pathogenesis
by: Cyril Jabea Ekabe, et al.
Published: (2022-01-01)

The transcription factor HMGB2 indirectly regulates APRIL expression and Gd-IgA1 production in patients with IgA nephropathy
by: Huijuan Tian, et al.
Published: (2024-12-01)

The Mechanism of Metabolic Influences on the Endogenous GLP-1 by Oral Antidiabetic Medications in Type 2 Diabetes Mellitus
by: Thiquynhnga Nguyen, et al.
Published: (2020-01-01)

Evaluation of the Biomarkers HMGB1 and IL-6 as Predictors of Mortality in Cirrhotic Patients with Acute Kidney Injury
by: Célio Geraldo de Oliveira Gomes, et al.
Published: (2020-01-01)

HMGB-1 as a Novel Predictor of Disease Severity and Prognosis in Patients with Hemorrhagic Fever with Renal Syndrome
by: Hong Du, et al.
Published: (2015-01-01)

Alarmins HMGB1, IL-33, S100A7, and S100A12 in Psoriasis Vulgaris
by: Pavel Borsky, et al.
Published: (2020-01-01)

The RNA-binding protein Puf5 and the HMGB protein Ixr1 regulate cell cycle-specific expression of CLB1 and CLB2 in Saccharomyces cerevisiae.
by: Megumi Sato, et al.
Published: (2025-01-01)

Effect of Social Factors and the Natural Environment on the Etiology and Pathogenesis of Diabetes Mellitus
by: Guangtong Dong, et al.
Published: (2019-01-01)

Decreased sirtuin 1 in type 2 diabetes patients with abnormal BMD
by: Yao Xu, et al.
Published: (2025-01-01)

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis
by: Mohsin H. K. Roshan, et al.
Published: (2016-01-01)

Quality of Life in University Students with Diabetes Distress: Type 1 and Type 2 of Diabetes Differences
by: Samah A. Moawd
Published: (2022-01-01)

Microbial dysbiosis in periodontitis and peri-implantitis: pathogenesis, immune responses, and therapeutic
by: Ziwei Cui, et al.
Published: (2025-02-01)

HMGB-1 as a predictor of major bleeding requiring activation of a massive transfusion protocol in severe trauma
by: Michal Frelich, et al.
Published: (2025-02-01)