A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia
Background. Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia which is a precancerous lesion. The lesion is usually developed at the limbal region and grows towards central cornea in association with neovascularization into the lesion. Here, we report a case of is...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Ophthalmological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2016/5687285 |
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| author | Tomoya Morii Takayoshi Sumioka Ai Izutani-Kitano Yukihisa Takada Yuka Okada Winston W.-Y. Kao Shizuya Saika |
| author_facet | Tomoya Morii Takayoshi Sumioka Ai Izutani-Kitano Yukihisa Takada Yuka Okada Winston W.-Y. Kao Shizuya Saika |
| author_sort | Tomoya Morii |
| collection | DOAJ |
| description | Background. Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia which is a precancerous lesion. The lesion is usually developed at the limbal region and grows towards central cornea in association with neovascularization into the lesion. Here, we report a case of isolated nonvascularized corneal epithelial dysplasia surrounded by normal corneal epithelium with immune histochemical finding of ocular surface tissues cytokeratins, for example, keratin 13 and keratin 12. Case Presentation. A 76-year-old man consulted us for visual disturbance with localized opacification of the corneal epithelium in his left eye. His visual acuity was 20/20 and 20/200 in his right and left eye, respectively. Slit lamp examination showed a whitish plaque-like lesion at the center of his left corneal epithelium. No vascular invasion to the lesion was found. The lesion was surgically removed and subjected to histopathological examination and diagnosed as epithelial dysplasia. Amyloidosis was excluded by direct fast scarlet 4BS (DFS) staining. Immunohistochemistry showed that the dysplastic epithelial cells express keratin 13 and vimentin, but not keratin 12, indicating that the neoplastic epithelial cells lacked corneal-type epithelium differentiation. Conclusions. The lesion was diagnosed as nonvascularized epithelial dysplasia of ocular surface. Etiology of the lesion is not known. |
| format | Article |
| id | doaj-art-2fd1944846aa426383190934c7d1292b |
| institution | DOAJ |
| issn | 2090-6722 2090-6730 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Ophthalmological Medicine |
| spelling | doaj-art-2fd1944846aa426383190934c7d1292b2025-08-20T03:20:22ZengWileyCase Reports in Ophthalmological Medicine2090-67222090-67302016-01-01201610.1155/2016/56872855687285A Case of Solitary Nonvascularized Corneal Epithelial DysplasiaTomoya Morii0Takayoshi Sumioka1Ai Izutani-Kitano2Yukihisa Takada3Yuka Okada4Winston W.-Y. Kao5Shizuya Saika6Department of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanDepartment of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanDepartment of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanDepartment of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanDepartment of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanDepartment of Ophthalmology, University of Cincinnati School of Medicine, Cincinnati, OH, USADepartment of Ophthalmology, Wakayama Medical University School of Medicine, Wakayama, JapanBackground. Epithelial dysplasia is categorized as conjunctival/corneal intraepithelial neoplasia which is a precancerous lesion. The lesion is usually developed at the limbal region and grows towards central cornea in association with neovascularization into the lesion. Here, we report a case of isolated nonvascularized corneal epithelial dysplasia surrounded by normal corneal epithelium with immune histochemical finding of ocular surface tissues cytokeratins, for example, keratin 13 and keratin 12. Case Presentation. A 76-year-old man consulted us for visual disturbance with localized opacification of the corneal epithelium in his left eye. His visual acuity was 20/20 and 20/200 in his right and left eye, respectively. Slit lamp examination showed a whitish plaque-like lesion at the center of his left corneal epithelium. No vascular invasion to the lesion was found. The lesion was surgically removed and subjected to histopathological examination and diagnosed as epithelial dysplasia. Amyloidosis was excluded by direct fast scarlet 4BS (DFS) staining. Immunohistochemistry showed that the dysplastic epithelial cells express keratin 13 and vimentin, but not keratin 12, indicating that the neoplastic epithelial cells lacked corneal-type epithelium differentiation. Conclusions. The lesion was diagnosed as nonvascularized epithelial dysplasia of ocular surface. Etiology of the lesion is not known.http://dx.doi.org/10.1155/2016/5687285 |
| spellingShingle | Tomoya Morii Takayoshi Sumioka Ai Izutani-Kitano Yukihisa Takada Yuka Okada Winston W.-Y. Kao Shizuya Saika A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia Case Reports in Ophthalmological Medicine |
| title | A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia |
| title_full | A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia |
| title_fullStr | A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia |
| title_full_unstemmed | A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia |
| title_short | A Case of Solitary Nonvascularized Corneal Epithelial Dysplasia |
| title_sort | case of solitary nonvascularized corneal epithelial dysplasia |
| url | http://dx.doi.org/10.1155/2016/5687285 |
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