Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer

Thrombospondin-1 induces CD8+ T cell exhaustion and immune suppression within the tumor microenvironment of ovarian cancer

Abstract Background Ovarian cancer (OC) progression is heavily influenced by the tumor microenvironment (TME), where immune suppression plays a critical role. This study explores the role of thrombospondin-1 (THBS1) in regulating tumor-associated macrophages (TAMs), T cell exhaustion, and immune che...

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Bibliographic Details
Main Authors: Haiyan Liang, Suwei Zhang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Thrombospondin-1
Tumor microenvironment
Immune suppression
T cell exhaustion
Online Access:https://doi.org/10.1186/s13048-025-01668-5
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https://doi.org/10.1186/s13048-025-01668-5

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