Colonization of pregnant women with group B streptococcus: current view at the problem
The relevance of the problem of group B streptococcus (GBS) in obstetric practice casts no doubt. Attracting the close attention of leading experts, introducing new solutions and based on practical experience gained, it is still not possible to prevent all cases of neonatal infections associated wit...
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| Format: | Article |
| Language: | Russian |
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IRBIS LLC
2022-05-01
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| Series: | Акушерство, гинекология и репродукция |
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| Online Access: | https://www.gynecology.su/jour/article/view/1230 |
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| author | A. S. Olenev A. G. Konopliannikov E. N. Songolova O. V. Stetsyuk |
| author_facet | A. S. Olenev A. G. Konopliannikov E. N. Songolova O. V. Stetsyuk |
| author_sort | A. S. Olenev |
| collection | DOAJ |
| description | The relevance of the problem of group B streptococcus (GBS) in obstetric practice casts no doubt. Attracting the close attention of leading experts, introducing new solutions and based on practical experience gained, it is still not possible to prevent all cases of neonatal infections associated with GBS. The review article demonstrates the current view of the problem. According to the literature, African-American race in combination with sexually transmitted infections are predisposing risk factors for GBS colonization. A direct relationship between obesity and the percentage of GBS carriers was revealed. GBS-colonized primigravidas have a 50 % increased chance of detecting the pathogen in subsequent pregnancies. Absolute factors for massive GBS colonization of the birth tract include GBS-associated asymptomatic bacteriuria and a history of GBS-colonized children. It is assumed that such virulence factors as hemolytic pigment and hyaluronidase contribute to the GBS pathogenic potential. The protective function in the immune system is performed by Kaschenko–Gofbauer cells, but their role is ambiguous. Early neonatal GBS infection realized in 90 % of newborns that manifested by sepsis, pneumonia and purulent meningitis. Implemented measures to prevent early neonatal GBS infection have a number of disadvantages. False-negative results of culture screening for GBS antigen at gestational age of 35–37 weeks increase a risk of vertical transmission, whereas false-positive results underlie a reason for prescribing irrational intranatal antibiotic prophylaxis. Moreover, antenatal GBS microbiological screening and antibiotic prophylaxis at birth do not prevent the risks of late-onset neonatal GBS infection. |
| format | Article |
| id | doaj-art-2fc97f5552504ab7befec11022913489 |
| institution | DOAJ |
| issn | 2313-7347 2500-3194 |
| language | Russian |
| publishDate | 2022-05-01 |
| publisher | IRBIS LLC |
| record_format | Article |
| series | Акушерство, гинекология и репродукция |
| spelling | doaj-art-2fc97f5552504ab7befec110229134892025-08-20T02:53:55ZrusIRBIS LLCАкушерство, гинекология и репродукция2313-73472500-31942022-05-0116218219310.17749/2313-7347/ob.gyn.rep.2022.284701Colonization of pregnant women with group B streptococcus: current view at the problemA. S. Olenev0A. G. Konopliannikov1E. N. Songolova2O. V. Stetsyuk3Perinatal Center – Branch of City Clinical Hospital № 24, Moscow Healthcare DepartmentPirogov Russian National Research Medical University, Health Ministry of Russian FederationVorokhobov City Clinical Hospital № 67, Moscow Healthcare DepartmentPirogov Russian National Research Medical University, Health Ministry of Russian FederationThe relevance of the problem of group B streptococcus (GBS) in obstetric practice casts no doubt. Attracting the close attention of leading experts, introducing new solutions and based on practical experience gained, it is still not possible to prevent all cases of neonatal infections associated with GBS. The review article demonstrates the current view of the problem. According to the literature, African-American race in combination with sexually transmitted infections are predisposing risk factors for GBS colonization. A direct relationship between obesity and the percentage of GBS carriers was revealed. GBS-colonized primigravidas have a 50 % increased chance of detecting the pathogen in subsequent pregnancies. Absolute factors for massive GBS colonization of the birth tract include GBS-associated asymptomatic bacteriuria and a history of GBS-colonized children. It is assumed that such virulence factors as hemolytic pigment and hyaluronidase contribute to the GBS pathogenic potential. The protective function in the immune system is performed by Kaschenko–Gofbauer cells, but their role is ambiguous. Early neonatal GBS infection realized in 90 % of newborns that manifested by sepsis, pneumonia and purulent meningitis. Implemented measures to prevent early neonatal GBS infection have a number of disadvantages. False-negative results of culture screening for GBS antigen at gestational age of 35–37 weeks increase a risk of vertical transmission, whereas false-positive results underlie a reason for prescribing irrational intranatal antibiotic prophylaxis. Moreover, antenatal GBS microbiological screening and antibiotic prophylaxis at birth do not prevent the risks of late-onset neonatal GBS infection.https://www.gynecology.su/jour/article/view/1230pregnancygroup b streptococcusgbsneonatal infections |
| spellingShingle | A. S. Olenev A. G. Konopliannikov E. N. Songolova O. V. Stetsyuk Colonization of pregnant women with group B streptococcus: current view at the problem Акушерство, гинекология и репродукция pregnancy group b streptococcus gbs neonatal infections |
| title | Colonization of pregnant women with group B streptococcus: current view at the problem |
| title_full | Colonization of pregnant women with group B streptococcus: current view at the problem |
| title_fullStr | Colonization of pregnant women with group B streptococcus: current view at the problem |
| title_full_unstemmed | Colonization of pregnant women with group B streptococcus: current view at the problem |
| title_short | Colonization of pregnant women with group B streptococcus: current view at the problem |
| title_sort | colonization of pregnant women with group b streptococcus current view at the problem |
| topic | pregnancy group b streptococcus gbs neonatal infections |
| url | https://www.gynecology.su/jour/article/view/1230 |
| work_keys_str_mv | AT asolenev colonizationofpregnantwomenwithgroupbstreptococcuscurrentviewattheproblem AT agkonopliannikov colonizationofpregnantwomenwithgroupbstreptococcuscurrentviewattheproblem AT ensongolova colonizationofpregnantwomenwithgroupbstreptococcuscurrentviewattheproblem AT ovstetsyuk colonizationofpregnantwomenwithgroupbstreptococcuscurrentviewattheproblem |