Antenatal prevention of mother to child transmission of HIV
An effective perinatal mother to child transmission (PMTCT) programme will reduce perinatal acquired HIV infections. This goal is within reach of the South African public health sector. Early antenatal attendance and knowledge of HIV status allows sufficient time to implement highly active antiretro...
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| Language: | English |
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AOSIS
2007-10-01
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| Series: | South African Family Practice |
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| Online Access: | https://safpj.co.za/index.php/safpj/article/view/968 |
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| author | G.B. Theron |
| author_facet | G.B. Theron |
| author_sort | G.B. Theron |
| collection | DOAJ |
| description | An effective perinatal mother to child transmission (PMTCT) programme will reduce perinatal acquired HIV infections. This goal is within reach of the South African public health sector. Early antenatal attendance and knowledge of HIV status allows sufficient time to implement highly active antiretroviral therapy (HAART) or ART intervention. Both measures have been proved to be efficient to reduce MTCT of HIV. A transmission rate of 2% can be achieved with a dual therapy regimen in non-breastfeedingwomen. Mono therapy with single dose nevirapine (sd NVP) often fails due to the once off nature of the intervention as opposed to ample opportunity to administer zudovudine (AZT) antenatally with dual therapy. A higher CD4 threshold to initiate HAART increases the window of opportunity while women are reasonably healthy. Irrespective of the maternal disease the newborn babies receive the same ART regimen. Women requiring HAART following pregnancy with an interval of 6 months or longer since NVP exposure had the same virological response as compared to NVP naïve women. Dual or mono therapy for a second time will be as effective as with NVP naïve women. The present day routine use of ART will reduce the risk of obstetric interventions. |
| format | Article |
| id | doaj-art-2fc6e77c39a147f88a6c0e42385bdb00 |
| institution | Kabale University |
| issn | 2078-6190 2078-6204 |
| language | English |
| publishDate | 2007-10-01 |
| publisher | AOSIS |
| record_format | Article |
| series | South African Family Practice |
| spelling | doaj-art-2fc6e77c39a147f88a6c0e42385bdb002025-08-20T03:43:47ZengAOSISSouth African Family Practice2078-61902078-62042007-10-0149910.1080/20786204.2007.10873645813Antenatal prevention of mother to child transmission of HIVG.B. Theron0Stellenbosch University, South Africa; and, Tygerberg HospitalAn effective perinatal mother to child transmission (PMTCT) programme will reduce perinatal acquired HIV infections. This goal is within reach of the South African public health sector. Early antenatal attendance and knowledge of HIV status allows sufficient time to implement highly active antiretroviral therapy (HAART) or ART intervention. Both measures have been proved to be efficient to reduce MTCT of HIV. A transmission rate of 2% can be achieved with a dual therapy regimen in non-breastfeedingwomen. Mono therapy with single dose nevirapine (sd NVP) often fails due to the once off nature of the intervention as opposed to ample opportunity to administer zudovudine (AZT) antenatally with dual therapy. A higher CD4 threshold to initiate HAART increases the window of opportunity while women are reasonably healthy. Irrespective of the maternal disease the newborn babies receive the same ART regimen. Women requiring HAART following pregnancy with an interval of 6 months or longer since NVP exposure had the same virological response as compared to NVP naïve women. Dual or mono therapy for a second time will be as effective as with NVP naïve women. The present day routine use of ART will reduce the risk of obstetric interventions.https://safpj.co.za/index.php/safpj/article/view/968perinatal mother to child transmissionhivantenatal prevention |
| spellingShingle | G.B. Theron Antenatal prevention of mother to child transmission of HIV South African Family Practice perinatal mother to child transmission hiv antenatal prevention |
| title | Antenatal prevention of mother to child transmission of HIV |
| title_full | Antenatal prevention of mother to child transmission of HIV |
| title_fullStr | Antenatal prevention of mother to child transmission of HIV |
| title_full_unstemmed | Antenatal prevention of mother to child transmission of HIV |
| title_short | Antenatal prevention of mother to child transmission of HIV |
| title_sort | antenatal prevention of mother to child transmission of hiv |
| topic | perinatal mother to child transmission hiv antenatal prevention |
| url | https://safpj.co.za/index.php/safpj/article/view/968 |
| work_keys_str_mv | AT gbtheron antenatalpreventionofmothertochildtransmissionofhiv |