Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis.
<h4>Purpose</h4>Tumor-associated neutrophils (TAN) have been reported in a variety of malignancies. We conducted an up-to-date meta-analysis to evaluate the prognostic role of TAN in cancer.<h4>Method</h4>Pubmed, Embase and web of science databases were searched for studies p...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0098259 |
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| author | Meixiao Shen Pingping Hu Frede Donskov Guanghui Wang Qi Liu Jiajun Du |
| author_facet | Meixiao Shen Pingping Hu Frede Donskov Guanghui Wang Qi Liu Jiajun Du |
| author_sort | Meixiao Shen |
| collection | DOAJ |
| description | <h4>Purpose</h4>Tumor-associated neutrophils (TAN) have been reported in a variety of malignancies. We conducted an up-to-date meta-analysis to evaluate the prognostic role of TAN in cancer.<h4>Method</h4>Pubmed, Embase and web of science databases were searched for studies published up to April 2013. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. The impact of neutrophils localization and primary antibody were also assessed.<h4>Results</h4>A total of 3946 patients with various solid tumors from 20 studies were included. High density of intratumoral neutrophils were independently associated with unfavorable survival; the pooled HRs were 1.68 (95%CI: 1.36-2.07, I2 = 55.8%, p<0.001) for recurrence-free survival (RFS)/disease-free survival (DFS), 3.36 (95%CI: 2.08-5.42, I2 = 0%, p<0.001) for cancer-specific survival (CSS) and 1.66 (95%CI: 1.37-2.01, I2 = 70.5%, p<0.001) for overall survival (OS). Peritumoral and stromal neutrophils were not statistically significantly associated with survival. When grouped by primary antibody, the pooled HRs were 1.80 (95%CI: 1.47-2.22, I2 = 67.7%, p<0.001) for CD66b, and 1.44 (95%CI: 0.90-2.30, I2 = 45.9%, p = 0.125) for CD15, suggesting that CD66b positive TAN might have a better prognostic value than CD15.<h4>Conclusion</h4>High levels of intratumoral neutrophils are associated with unfavorable recurrence-free, cancer-specific and overall survival. |
| format | Article |
| id | doaj-art-2fc29dc27acc44f2b74355a1d4c36df2 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-2fc29dc27acc44f2b74355a1d4c36df22025-08-20T03:31:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e9825910.1371/journal.pone.0098259Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis.Meixiao ShenPingping HuFrede DonskovGuanghui WangQi LiuJiajun Du<h4>Purpose</h4>Tumor-associated neutrophils (TAN) have been reported in a variety of malignancies. We conducted an up-to-date meta-analysis to evaluate the prognostic role of TAN in cancer.<h4>Method</h4>Pubmed, Embase and web of science databases were searched for studies published up to April 2013. Pooled hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) were calculated. The impact of neutrophils localization and primary antibody were also assessed.<h4>Results</h4>A total of 3946 patients with various solid tumors from 20 studies were included. High density of intratumoral neutrophils were independently associated with unfavorable survival; the pooled HRs were 1.68 (95%CI: 1.36-2.07, I2 = 55.8%, p<0.001) for recurrence-free survival (RFS)/disease-free survival (DFS), 3.36 (95%CI: 2.08-5.42, I2 = 0%, p<0.001) for cancer-specific survival (CSS) and 1.66 (95%CI: 1.37-2.01, I2 = 70.5%, p<0.001) for overall survival (OS). Peritumoral and stromal neutrophils were not statistically significantly associated with survival. When grouped by primary antibody, the pooled HRs were 1.80 (95%CI: 1.47-2.22, I2 = 67.7%, p<0.001) for CD66b, and 1.44 (95%CI: 0.90-2.30, I2 = 45.9%, p = 0.125) for CD15, suggesting that CD66b positive TAN might have a better prognostic value than CD15.<h4>Conclusion</h4>High levels of intratumoral neutrophils are associated with unfavorable recurrence-free, cancer-specific and overall survival.https://doi.org/10.1371/journal.pone.0098259 |
| spellingShingle | Meixiao Shen Pingping Hu Frede Donskov Guanghui Wang Qi Liu Jiajun Du Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. PLoS ONE |
| title | Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. |
| title_full | Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. |
| title_fullStr | Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. |
| title_full_unstemmed | Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. |
| title_short | Tumor-associated neutrophils as a new prognostic factor in cancer: a systematic review and meta-analysis. |
| title_sort | tumor associated neutrophils as a new prognostic factor in cancer a systematic review and meta analysis |
| url | https://doi.org/10.1371/journal.pone.0098259 |
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