Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats
Background and purpose: Cardiac mitochondria dysfunction plays a central pathophysiological role in the abnormal glucose metabolism in the heart and in diabetic cardiomyopathy. The present study evaluated the effects of flavonoid glycoside naringin treatment on the interconnection between changes i...
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International Association of Physical Chemists (IAPC)
2025-01-01
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| Series: | ADMET and DMPK |
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| Online Access: | https://pub.iapchem.org/ojs/index.php/admet/article/view/2571 |
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| author | Ilya Zavodnik Tatsiana A. Kavalenia Siarhei N. Kirko Elena B. Belonovskaya Irina A. Kuzmitskaya Yulia V. Eroshenko Elena A. Lapshina Vyacheslav U. Buko |
| author_facet | Ilya Zavodnik Tatsiana A. Kavalenia Siarhei N. Kirko Elena B. Belonovskaya Irina A. Kuzmitskaya Yulia V. Eroshenko Elena A. Lapshina Vyacheslav U. Buko |
| author_sort | Ilya Zavodnik |
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Background and purpose: Cardiac mitochondria dysfunction plays a central pathophysiological role in the abnormal glucose metabolism in the heart and in diabetic cardiomyopathy. The present study evaluated the effects of flavonoid glycoside naringin treatment on the interconnection between changes in cardiac mitochondria oxygen consumption, membrane potential and mitochondrial Ca2+ sensitivity during type 1 diabetes. Experimental approach: Type 1 diabetes was induced by an intraperitoneal injection of streptozotocin (40 mg/kg) in rats and islet morphology, glucose and insulin levels, changes in heart mitochondria respiration, membrane potential, spontaneous and Ca2+ - induced mitochondrial permeability transition (MPT) pore opening were evaluated. Key results: Diabetes resulted in typical signs of hyperglycemia, which were accompanied by a rat cardiac mitochondria dysfunction, manifested by decreased V2 and V3 rates of oxygen consumption, while the initial membrane potential value remained unchanged. The rates of Ca2+-induced MPT pore opening and Ca2+-induced membrane potential dissipation in isolated mitochondria decreased under type 1 diabetes. The naringin treatment (40 mg/kg of the body weight, 4 weeks) partially recovered impaired cardiac mitochondria respiration, decreased spontaneous and increased Ca2+-induced MPT pore opening, improved pancreatic islets morphology and dystrophic changes, lowered glycated hemoglobin and blood plasma urea, and decreased the oxidative stress level with glucose or insulin concentrations remaining unchanged in diabetic animals. Conclusions: Naringin administration demonstrated beneficial effects during type 1 diabetes and represents a promising therapeutic (or nutriceutical) approach for diabetes treatment.
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| format | Article |
| id | doaj-art-2fc096096ae244a184d811402cdd445d |
| institution | Kabale University |
| issn | 1848-7718 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | International Association of Physical Chemists (IAPC) |
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| series | ADMET and DMPK |
| spelling | doaj-art-2fc096096ae244a184d811402cdd445d2025-01-26T07:47:32ZengInternational Association of Physical Chemists (IAPC)ADMET and DMPK1848-77182025-01-0110.5599/admet.2571Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats Ilya Zavodnik0Tatsiana A. Kavalenia 1Siarhei N. Kirko 2Elena B. Belonovskaya 3Irina A. Kuzmitskaya 4Yulia V. Eroshenko 5Elena A. Lapshina 6Vyacheslav U. Buko 7Department of Biochemistry, Yanka Kupala State University of Grodno, Bulvar Leninskogo Komsomola, 5, 230009 Grodno, Grodno, Belarus Department of Biochemistry, Yanka Kupala State University of Grodno, Bulvar Leninskogo Komsomola, 5, 230009 Grodno, Grodno, Belarus Division of Biochemical Pharmacology, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences, Bulvar Leninskogo Komsomola, 50, 230030 Grodno, BelarusDivision of Biochemical Pharmacology, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences, Bulvar Leninskogo Komsomola, 50, 230030 Grodno, BelarusDivision of Biochemical Pharmacology, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences, Bulvar Leninskogo Komsomola, 50, 230030 Grodno, BelarusDivision of Biochemical Pharmacology, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences, Bulvar Leninskogo Komsomola, 50, 230030 Grodno, BelarusDepartment of Biochemistry, Yanka Kupala State University of Grodno, Bulvar Leninskogo Komsomola, 5, 230009 Grodno, Grodno, Belarus Division of Biochemical Pharmacology, Institute of Biochemistry of Biologically Active Compounds, National Academy of Sciences, Bulvar Leninskogo Komsomola, 50, 230030 Grodno, Belarus Background and purpose: Cardiac mitochondria dysfunction plays a central pathophysiological role in the abnormal glucose metabolism in the heart and in diabetic cardiomyopathy. The present study evaluated the effects of flavonoid glycoside naringin treatment on the interconnection between changes in cardiac mitochondria oxygen consumption, membrane potential and mitochondrial Ca2+ sensitivity during type 1 diabetes. Experimental approach: Type 1 diabetes was induced by an intraperitoneal injection of streptozotocin (40 mg/kg) in rats and islet morphology, glucose and insulin levels, changes in heart mitochondria respiration, membrane potential, spontaneous and Ca2+ - induced mitochondrial permeability transition (MPT) pore opening were evaluated. Key results: Diabetes resulted in typical signs of hyperglycemia, which were accompanied by a rat cardiac mitochondria dysfunction, manifested by decreased V2 and V3 rates of oxygen consumption, while the initial membrane potential value remained unchanged. The rates of Ca2+-induced MPT pore opening and Ca2+-induced membrane potential dissipation in isolated mitochondria decreased under type 1 diabetes. The naringin treatment (40 mg/kg of the body weight, 4 weeks) partially recovered impaired cardiac mitochondria respiration, decreased spontaneous and increased Ca2+-induced MPT pore opening, improved pancreatic islets morphology and dystrophic changes, lowered glycated hemoglobin and blood plasma urea, and decreased the oxidative stress level with glucose or insulin concentrations remaining unchanged in diabetic animals. Conclusions: Naringin administration demonstrated beneficial effects during type 1 diabetes and represents a promising therapeutic (or nutriceutical) approach for diabetes treatment. https://pub.iapchem.org/ojs/index.php/admet/article/view/2571Cardiac mitochondriaflavonoidsrespirationislets |
| spellingShingle | Ilya Zavodnik Tatsiana A. Kavalenia Siarhei N. Kirko Elena B. Belonovskaya Irina A. Kuzmitskaya Yulia V. Eroshenko Elena A. Lapshina Vyacheslav U. Buko Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats ADMET and DMPK Cardiac mitochondria flavonoids respiration islets |
| title | Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| title_full | Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| title_fullStr | Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| title_full_unstemmed | Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| title_short | Naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| title_sort | naringin prevents heart mitochondria dysfunction during diabetic cardiomyopathy in rats |
| topic | Cardiac mitochondria flavonoids respiration islets |
| url | https://pub.iapchem.org/ojs/index.php/admet/article/view/2571 |
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