Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety
The aim was to evaluate the effect of the combined butyrate and inulin supplement administered as an adjuvant to Helicobacter pylori eradication therapy (ET) on treatment outcome. 349 patients with chronic gastroduodenal diseases and infected H. pylori were еxamined. A comparative analysis of the ef...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | Russian |
| Published: |
Open Systems Publication
2021-06-01
|
| Series: | Лечащий Врач |
| Subjects: | |
| Online Access: | https://journal.lvrach.ru/jour/article/view/222 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850065348898848768 |
|---|---|
| author | M. D. Ardatskaya T. B. Topchiy L. I. Butorova E. V. Sayutina E. M. Tuaeva Yu. N. Loschinina M. P. Egorycheva N. N. Makarova N. Yu. Anikina G. F. Saidova E. G. Melnikova L. N. Proskuratova N. G. Kadnikova M. A. Kalashnikova E. V. Marchenko L. N. Pavlova M. S. Yakovenko V. L. Mogilnaya N. V. Krapivnaya |
| author_facet | M. D. Ardatskaya T. B. Topchiy L. I. Butorova E. V. Sayutina E. M. Tuaeva Yu. N. Loschinina M. P. Egorycheva N. N. Makarova N. Yu. Anikina G. F. Saidova E. G. Melnikova L. N. Proskuratova N. G. Kadnikova M. A. Kalashnikova E. V. Marchenko L. N. Pavlova M. S. Yakovenko V. L. Mogilnaya N. V. Krapivnaya |
| author_sort | M. D. Ardatskaya |
| collection | DOAJ |
| description | The aim was to evaluate the effect of the combined butyrate and inulin supplement administered as an adjuvant to Helicobacter pylori eradication therapy (ET) on treatment outcome. 349 patients with chronic gastroduodenal diseases and infected H. pylori were еxamined. A comparative analysis of the effect of a combined butyrate and inulin supplement on improving the effectiveness of the optimized ET regimen, improving its tolerability and patients’ compliance. The success of eradication was controlled by a 13C urease breath test. Significantly higher eradication rates were observed in the ET + combined butyrate and inulin supplement group (91,3% versus 74,4%, р˂ 0,05), compared with the control group (ET only). A lower incidence of side effects (bloating, rumbling, diarrhea, bitterness in the mouth) by the end of the 14-day course of treatment was noted in the ET + combined butyrate and inulin supplement group (p˂ 0,01). Significantly higher patient adherence rates (87% versus 63%, p = 0.04) and a lower discontinuation rates of ET (χ2 = 8.22, p = 0.0041) were also noted in the ET + combined butyrate and inulin supplement group, compared with control group (ET only). The adjuvant administration of a combined supplement of butyric acid and inulin to a standard three-component ET regimen significantly increases the effectiveness of treatment and is associated with less self-reported side effects (diarrhea, bloating, bitterness in the mouth), lower side effects-related treatment discontinuation rates and higher treatment compliance. |
| format | Article |
| id | doaj-art-2fbdcd1cfe8a46988d75bdab7c67b551 |
| institution | DOAJ |
| issn | 1560-5175 2687-1181 |
| language | Russian |
| publishDate | 2021-06-01 |
| publisher | Open Systems Publication |
| record_format | Article |
| series | Лечащий Врач |
| spelling | doaj-art-2fbdcd1cfe8a46988d75bdab7c67b5512025-08-20T02:49:02ZrusOpen Systems PublicationЛечащий Врач1560-51752687-11812021-06-01011525910.26295/OS.2020.31.57.011221Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safetyM. D. Ardatskaya0T. B. Topchiy1L. I. Butorova2E. V. Sayutina3E. M. Tuaeva4Yu. N. Loschinina5M. P. Egorycheva6N. N. Makarova7N. Yu. Anikina8G. F. Saidova9E. G. Melnikova10L. N. Proskuratova11N. G. Kadnikova12M. A. Kalashnikova13E. V. Marchenko14L. N. Pavlova15M. S. Yakovenko16V. L. Mogilnaya17N. V. Krapivnaya18Federal state budgetary institution of additional professional education «Central State Medical Academy» Administration of the President of the Russian FederationFederal state budgetary institution of additional professional education «Central State Medical Academy» Administration of the President of the Russian FederationN. I. Sechenov First Moscow State Medical UniversityN. I. Sechenov First Moscow State Medical UniversityN. I. Sechenov First Moscow State Medical UniversityThe Federal Budgetary Institution of Healthcare «Medical Rehabilitation Centre of the Ministry of Economic Development of Russia»Medical and Rehabilitation Clinical Center of the Ministry of Defense of the Russian FederationMedical and Rehabilitation Clinical Center of the Ministry of Defense of the Russian FederationMedical Center The Clinic K+31Medical Center The Clinic K+31Medical Center The SM-ClinicMedical Center The SM-ClinicFederal State Budgetary Institution of Health «Central Clinical Hospital for Rehabilitation of the Federal Medical and Biological Agency»Federal State Budgetary Institution «United Hospital with Polyclinic» of the Administrative Department of the President of the Russian FederationThe National Medical Research Center for EndocrinologyMedical Center «Axis»State Budget Health Care Institution «Scientific Research Institute – Ochapovsky Regional Clinical Hospital № 1»Clinic «Ekaterininskaya»«City polyclinic № 25 of Krasnodar»The aim was to evaluate the effect of the combined butyrate and inulin supplement administered as an adjuvant to Helicobacter pylori eradication therapy (ET) on treatment outcome. 349 patients with chronic gastroduodenal diseases and infected H. pylori were еxamined. A comparative analysis of the effect of a combined butyrate and inulin supplement on improving the effectiveness of the optimized ET regimen, improving its tolerability and patients’ compliance. The success of eradication was controlled by a 13C urease breath test. Significantly higher eradication rates were observed in the ET + combined butyrate and inulin supplement group (91,3% versus 74,4%, р˂ 0,05), compared with the control group (ET only). A lower incidence of side effects (bloating, rumbling, diarrhea, bitterness in the mouth) by the end of the 14-day course of treatment was noted in the ET + combined butyrate and inulin supplement group (p˂ 0,01). Significantly higher patient adherence rates (87% versus 63%, p = 0.04) and a lower discontinuation rates of ET (χ2 = 8.22, p = 0.0041) were also noted in the ET + combined butyrate and inulin supplement group, compared with control group (ET only). The adjuvant administration of a combined supplement of butyric acid and inulin to a standard three-component ET regimen significantly increases the effectiveness of treatment and is associated with less self-reported side effects (diarrhea, bloating, bitterness in the mouth), lower side effects-related treatment discontinuation rates and higher treatment compliance.https://journal.lvrach.ru/jour/article/view/222patient complianceeradicationhelicobacter pyloriside effectsantibiotic-associated diarrheabitterness in the mouthbutyric acid |
| spellingShingle | M. D. Ardatskaya T. B. Topchiy L. I. Butorova E. V. Sayutina E. M. Tuaeva Yu. N. Loschinina M. P. Egorycheva N. N. Makarova N. Yu. Anikina G. F. Saidova E. G. Melnikova L. N. Proskuratova N. G. Kadnikova M. A. Kalashnikova E. V. Marchenko L. N. Pavlova M. S. Yakovenko V. L. Mogilnaya N. V. Krapivnaya Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety Лечащий Врач patient compliance eradication helicobacter pylori side effects antibiotic-associated diarrhea bitterness in the mouth butyric acid |
| title | Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety |
| title_full | Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety |
| title_fullStr | Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety |
| title_full_unstemmed | Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety |
| title_short | Improving the effectiveness of H. pylori eradication therapy: focus on patient compliance and treatment safety |
| title_sort | improving the effectiveness of h pylori eradication therapy focus on patient compliance and treatment safety |
| topic | patient compliance eradication helicobacter pylori side effects antibiotic-associated diarrhea bitterness in the mouth butyric acid |
| url | https://journal.lvrach.ru/jour/article/view/222 |
| work_keys_str_mv | AT mdardatskaya improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT tbtopchiy improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT libutorova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT evsayutina improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT emtuaeva improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT yunloschinina improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT mpegorycheva improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT nnmakarova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT nyuanikina improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT gfsaidova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT egmelnikova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT lnproskuratova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT ngkadnikova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT makalashnikova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT evmarchenko improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT lnpavlova improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT msyakovenko improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT vlmogilnaya improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety AT nvkrapivnaya improvingtheeffectivenessofhpylorieradicationtherapyfocusonpatientcomplianceandtreatmentsafety |