TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis

TIMP1 inhibits Rac1-mediated ROS production to ameliorate blood–spinal cord barrier disruption in amyotrophic lateral sclerosis

Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the progressive degeneration of motor neurons, for which therapeutic strategies and pharmacological interventions remain limited. Disruption of the blood–spinal cord barrier (BSCB) has been identified as a significa...

Full description

Saved in:

Bibliographic Details
Main Authors:	Jingshu Tang, Yuying Kang, Qiuyu Chen, Baodan Zhang, Nianying Shang, Jiaqi Lan, Lei Wu, Ying Peng
Format:	Article
Language:	English
Published:	Elsevier 2025-09-01
Series:	Neurobiology of Disease
Subjects:	Amyotrophic lateral sclerosis Tissue inhibitor of metalloproteinase-1 Blood–spinal cord barrier Tight junction complexes Reactive oxygen species Cytoskeleton
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996125002037
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Astrocyte-derived MMP-9 is a key mediator of pseudorabies virus penetration of the blood–brain barrier and tight junction disruption
by: Ying Zhang, et al.
Published: (2025-04-01)

Role of MMP-2, MMP-9, TIMP-1, and TIMP-2 in children with ventricular septal defect
by: Nina Maric, et al.
Published: (2024-10-01)

Formation of tight junction-like structures of zonula occludens 2 in platelet–platelet interaction
by: Magdolna Nagy, et al.
Published: (2025-03-01)

Hemagglutinin Protease HapA Associated With Vibrio cholerae Outer Membrane Vesicles (OMVs) Disrupts Tight and Adherens Junctions
by: Palwasha Baryalai, et al.
Published: (2025-05-01)

Muramyl peptide blend ameliorates intestinal inflammation and barrier integrity in cell culture model
by: D.M. Masiuk, et al.
Published: (2024-09-01)

Restoring brain barriers: an innovative approach for treating neurological disorders
by: Sighild Lemarchant, et al.
Published: (2025-07-01)

Mechanisms of neuromuscular junction dysfunction in amyotrophic lateral sclerosis
by: Aydar N. Khabibrakhmanov, et al.
Published: (2025-04-01)

Hypoxia disrupts human bronchial epithelial barrier integrity via tight junction protein remodeling and enhanced paracellular leakage
by: Jianmin Huang, et al.
Published: (2025-08-01)

Expression of MMP1, MMP3, and TIMP1 in intervertebral discs under simulated overload and microgravity conditions
by: Xuanyu Chen, et al.
Published: (2025-01-01)

The PAR2 Antagonist Larazotide Can Mitigate Acute Histamine-Stimulated Epithelial Barrier Disruption in Keratinocytes: A Potential Adjunct Treatment for Atopic Dermatitis
by: Danielle M. Glinka, et al.
Published: (2025-07-01)

Complex studies on gene polymorphisms of MMP2, MMP3, MMP9 matrix metalloproteinases and TIMP1, TIMP2 tissue inhibitors of metalloproteinases in the patients with primary open-angle glaucoma
by: A. V. Shevchenko, et al.
Published: (2023-04-01)

SIRT7 remodels the cytoskeleton via RAC1 to enhance host resistance to Mycobacterium tuberculosis
by: Fuxiang Li, et al.
Published: (2024-10-01)

Experimental study of Rac1 regulating osteoclast function in hypoxic environment
by: GU Jiahong, et al.
Published: (2024-02-01)

Parameters of the mmp / timp system in assessing the clinical course of pulmonary tuberculoma
by: D. S. Esmedlyaeva, et al.
Published: (2024-04-01)

Perturbation of mammary epithelial cell apicobasal polarity by RHBDF1-facilitated nuclear translocation of PKCζ
by: Huan-Yu Zhao, et al.
Published: (2024-11-01)

Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction
by: Martin Sepulveda, et al.
Published: (2025-10-01)

Expression of MMP-2, MMP-9 and TIMP-2 in pituitary tumors and their relationship with cavernous sinus invasion
by: Ane Caroline Thé B Freire, et al.
Published: (2025-01-01)

Circadian misalignment potentiates blood-brain barrier disruption and mitochondria dysregulation in Zika virus infection
by: Timea Teglas, et al.
Published: (2025-06-01)

Expression of plasma levels of MMP-2, MMP-9, TIMP-1, and TIMP-2 in patients with abdominal aortic aneurysms
by: Túlio Fabiano de Oliveira Leite, et al.
Published: (2025-05-01)

Sodium arsenite induces islets β-cells apoptosis and dysfunction via SET-Rac1-mediated cytoskeleton disturbance
by: Tianming Qiu, et al.
Published: (2025-01-01)

Early Radiation-Induced Changes in Lung Tissue and Intercellular Junctions: Implications for Tissue Repair and Fibrosis
by: Ekaterina S. Karetnikova, et al.
Published: (2024-09-01)

Invadosomes as “shape-shifters” of cellular maturation: insights from megakaryocytes
by: Frédérique Gaits-Iacovoni
Published: (2025-08-01)

RhoA/ROCK2 signaling pathway regulates Mn-induced alterations in tight junction proteins leading to cognitive dysfunction in mice
by: Yan Ma, et al.
Published: (2025-01-01)

Exacerbation of polyethylene microplastics in animal models of DSS-induced colitis through damage to intestinal epithelial cell conjunctions
by: Minkyoung Sung, et al.
Published: (2025-01-01)

Matrix Metalloproteinases in Ureteropelvic Junction Obstruction: Their Role in Pathogenesis and Their Use as Clinical Markers
by: Giusi Alberti, et al.
Published: (2025-03-01)

Zonula occludens 1 as a novel biomarker in decompensated alcoholic cirrhosis with hepatorenal syndrome
by: Balasubramaniyan Vairappan, et al.
Published: (2025-05-01)

The effect of different exercise training protocols on MMP-9 and TIMP-1 gene expression in rat myocardium
by: Mehran Ghahremani, et al.
Published: (2023-01-01)

СURRENT CONCEPTS OF THE ROLE OF ALTERED BLOOD-BRAIN BARRIER RESISTANCE IN THE PATHOGENESIS OF CNS DISORDERS. PART II: FUNCTIONS AND MECHANISMS OF THE BLOOD-BRAIN BARRIER DAMAGE
by: D. V. Blinov
Published: (2016-05-01)

Mucosal barrier function and microbial community of small intestines in sheep in response to dietary energy concentrations
by: X.L. Wang, et al.
Published: (2025-07-01)

Histopathological investigation of the effect of coenzyme q10 on intestinal mucosa and tight junction proteins in experimental colitis model
by: Saadet Ozen Akarca Dizakar, et al.
Published: (2022-09-01)

Mechanism of Marinobufagenin-Induced Hyperpermeability of Human Brain Microvascular Endothelial Cell Monolayer: A Potential Pathogenesis of Seizure in Preeclampsia
by: Ahmed F. Pantho, et al.
Published: (2024-10-01)

Transcriptomics insights into glutamine on repairing of histamine-induced Yak rumen epithelial cells barrier damage in vitro
by: Xiaohong Zhang, et al.
Published: (2025-02-01)

Limosilactobacillus ingluviei C37 alleviates immunological stress and improves intestinal barrier gene expression in lipopolysaccharides challenged broiler chickens
by: Merisa Sirisopapong, et al.
Published: (2025-12-01)

Amonabactin Synthetase G Regulates <i>Aeromonas hydrophila</i> Pathogenicity Through Modulation of Host Wnt/β-catenin Signaling
by: Yiyang Tang, et al.
Published: (2025-02-01)

Tight junction protein changes in irritable bowel syndrome: the relation of age and disease severity
by: Sang Un Kim, et al.
Published: (2024-11-01)

Rumex japonicus Houtt. alleviates dextran sulfate sodium-induced colitis by protecting tight junctions in mice
by: Hee-Young Kim, et al.
Published: (2020-06-01)

Citral protects against metabolic endotoxemia, and systemic disorders caused by high-fat diet-induced obesity via intestinal modulation
by: Maycon Tavares Emílio-Silva, et al.
Published: (2025-04-01)

Microbial metabolites short chain fatty acids, tight junction, gap junction, and reproduction: a review
by: Lulu Fu, et al.
Published: (2025-08-01)

Pain in Amyotrophic Lateral Sclerosis Is Underrated
by: Soyoung Kwak, et al.
Published: (2024-12-01)

IgSF11–RAP1 signaling promotes cell migration and invasion of cutaneous melanoma
by: Yasuyuki Kobayashi, et al.
Published: (2025-07-01)